Molecular basis of atrial fibrillation pathophysiology and therapy: a translational perspective

S Nattel, J Heijman, L Zhou, D Dobrev - Circulation research, 2020 - Am Heart Assoc
Atrial fibrillation (AF) is a highly prevalent arrhythmia, with substantial associated morbidity
and mortality. There have been significant management advances over the past 2 decades …

2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation

H Calkins, G Hindricks, R Cappato, YH Kim… - Ep …, 2018 - academic.oup.com
AFL atrial flutter AH arterial hypertension ANS autonomic nervous system APD action
potential duration ARREST-AF Aggressive Risk Factor Reduction Study for Atrial Fibrillation …

Postoperative atrial fibrillation: mechanisms, manifestations and management

D Dobrev, M Aguilar, J Heijman, JB Guichard… - Nature Reviews …, 2019 - nature.com
Postoperative atrial fibrillation (POAF) complicates 20–40% of cardiac surgical procedures
and 10–20% of non-cardiac thoracic operations. Typical features include onset at 2–4 days …

Enhanced cardiomyocyte NLRP3 inflammasome signaling promotes atrial fibrillation

C Yao, T Veleva, L Scott Jr, S Cao, L Li, G Chen… - Circulation, 2018 - Am Heart Assoc
Background: Atrial fibrillation (AF) is frequently associated with enhanced inflammatory
response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3) inflammasome …

EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: definition, characterization, and clinical implication

A Goette, JM Kalman, L Aguinaga, J Akar… - Ep …, 2016 - academic.oup.com
The atria provide an important contribution to cardiac function. 1, 2 Besides their impact on
ventricular filling, they serve as a volume reservoir, host pacemaker cells and important parts …

Calcium signaling and cardiac arrhythmias

AP Landstrom, D Dobrev, XHT Wehrens - Circulation research, 2017 - Am Heart Assoc
There has been a significant progress in our understanding of the molecular mechanisms by
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …

[HTML][HTML] Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes

BS Karam, A Chavez-Moreno… - Cardiovascular …, 2017 - cardiab.biomedcentral.com
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans. Several
risk factors promote AF, among which diabetes mellitus has emerged as one of the most …

Atrial fibrillation and mechanisms of stroke: time for a new model

H Kamel, PM Okin, MSV Elkind, C Iadecola - Stroke, 2016 - Am Heart Assoc
896 Stroke March 2016 risk. However, in a meta-analysis of 8 randomized clinical trials, a
rhythm-control strategy had no effect on stroke risk (odds ratio, 0.99; 95% confidence …

The clinical profile and pathophysiology of atrial fibrillation: relationships among clinical features, epidemiology, and mechanisms

J Andrade, P Khairy, D Dobrev, S Nattel - Circulation research, 2014 - Am Heart Assoc
Atrial fibrillation (AF) is the most common arrhythmia (estimated lifetime risk, 22%–26%). The
aim of this article is to review the clinical epidemiological features of AF and to relate them to …

[HTML][HTML] Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior

V András, J Tomek, N Nagy, L Virág… - Physiological …, 2021 - journals.physiology.org
Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …