Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation
The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …
components across multiple spatial (from ion channel to organ) and temporal (from …
Altered atrial cytosolic calcium handling contributes to the development of postoperative atrial fibrillation
FE Fakuade, V Steckmeister, F Seibertz… - Cardiovascular …, 2021 - academic.oup.com
Aims Atrial fibrillation (AF) is a commonly occurring arrhythmia after cardiac surgery
(postoperative AF, poAF) and is associated with poorer outcomes. Considering that reduced …
(postoperative AF, poAF) and is associated with poorer outcomes. Considering that reduced …
[HTML][HTML] Mechanisms underlying antiarrhythmic properties of cardioprotective agents impacting inflammation and oxidative stress
K Andelova, BS Bacova, M Sykora, P Hlivak… - International Journal of …, 2022 - mdpi.com
The prevention of cardiac life-threatening ventricular fibrillation and stroke-provoking atrial
fibrillation remains a serious global clinical issue, with ongoing need for novel approaches …
fibrillation remains a serious global clinical issue, with ongoing need for novel approaches …
The role of the autonomic ganglia in atrial fibrillation
S Stavrakis, H Nakagawa, SS Po, BJ Scherlag… - JACC: Clinical …, 2015 - jacc.org
Recent experimental and clinical studies have shown that the epicardial autonomic ganglia
play an important role in the initiation and maintenance of atrial fibrillation (AF). In this …
play an important role in the initiation and maintenance of atrial fibrillation (AF). In this …
Diabetes mellitus and atrial fibrillation: pathophysiological mechanisms and potential upstream therapies
CA Goudis, P Korantzopoulos, IV Ntalas… - International journal of …, 2015 - Elsevier
Diabetes mellitus (DM) represents one of the most important risk factors for atrial fibrillation
(AF) while AF is a strong and independent marker of overall mortality and cardiovascular …
(AF) while AF is a strong and independent marker of overall mortality and cardiovascular …
Glucose fluctuations increase the incidence of atrial fibrillation in diabetic rats
S Saito, Y Teshima, A Fukui, H Kondo… - Cardiovascular …, 2014 - academic.oup.com
Aims We investigated whether glucose fluctuations aggravate cardiac fibrosis and increase
the occurrence of atrial fibrillation (AF) in rats with diabetes mellitus (DM). Methods and …
the occurrence of atrial fibrillation (AF) in rats with diabetes mellitus (DM). Methods and …
Downregulation of FKBP5 promotes atrial arrhythmogenesis
Background: Atrial fibrillation (AF), the most common arrhythmia, is associated with the
downregulation of FKBP5 (encoding FKBP5 [FK506 binding protein 5]). However, the …
downregulation of FKBP5 (encoding FKBP5 [FK506 binding protein 5]). However, the …
Left atrial remodeling mechanisms associated with atrial fibrillation
Heart disease has always been one of the important diseases that endanger health and
cause death. Therefore, it is particularly important to understand left atrium reconstruction …
cause death. Therefore, it is particularly important to understand left atrium reconstruction …
Murine electrophysiological models of cardiac arrhythmogenesis
CLH Huang - Physiological reviews, 2017 - journals.physiology.org
Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …
processes underlying excitable activity and their tissue propagation as coherent wavefronts …
[HTML][HTML] A biological rationale for the disparate effects of omega-3 fatty acids on cardiovascular disease outcomes
SCR Sherratt, P Libby, DL Bhatt, RP Mason - … , Leukotrienes and Essential …, 2022 - Elsevier
The omega-3 fatty acids (n3-FAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid
(DHA) rapidly incorporate into cell membranes where they modulate signal transduction …
(DHA) rapidly incorporate into cell membranes where they modulate signal transduction …