Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation

NA Trayanova, A Lyon, J Shade… - Physiological …, 2024 - journals.physiology.org
The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …

Altered atrial cytosolic calcium handling contributes to the development of postoperative atrial fibrillation

FE Fakuade, V Steckmeister, F Seibertz… - Cardiovascular …, 2021 - academic.oup.com
Aims Atrial fibrillation (AF) is a commonly occurring arrhythmia after cardiac surgery
(postoperative AF, poAF) and is associated with poorer outcomes. Considering that reduced …

[HTML][HTML] Mechanisms underlying antiarrhythmic properties of cardioprotective agents impacting inflammation and oxidative stress

K Andelova, BS Bacova, M Sykora, P Hlivak… - International Journal of …, 2022 - mdpi.com
The prevention of cardiac life-threatening ventricular fibrillation and stroke-provoking atrial
fibrillation remains a serious global clinical issue, with ongoing need for novel approaches …

The role of the autonomic ganglia in atrial fibrillation

S Stavrakis, H Nakagawa, SS Po, BJ Scherlag… - JACC: Clinical …, 2015 - jacc.org
Recent experimental and clinical studies have shown that the epicardial autonomic ganglia
play an important role in the initiation and maintenance of atrial fibrillation (AF). In this …

Diabetes mellitus and atrial fibrillation: pathophysiological mechanisms and potential upstream therapies

CA Goudis, P Korantzopoulos, IV Ntalas… - International journal of …, 2015 - Elsevier
Diabetes mellitus (DM) represents one of the most important risk factors for atrial fibrillation
(AF) while AF is a strong and independent marker of overall mortality and cardiovascular …

Glucose fluctuations increase the incidence of atrial fibrillation in diabetic rats

S Saito, Y Teshima, A Fukui, H Kondo… - Cardiovascular …, 2014 - academic.oup.com
Aims We investigated whether glucose fluctuations aggravate cardiac fibrosis and increase
the occurrence of atrial fibrillation (AF) in rats with diabetes mellitus (DM). Methods and …

Downregulation of FKBP5 promotes atrial arrhythmogenesis

X Wang, J Song, Y Yuan, L Li, I Abu-Taha… - Circulation …, 2023 - Am Heart Assoc
Background: Atrial fibrillation (AF), the most common arrhythmia, is associated with the
downregulation of FKBP5 (encoding FKBP5 [FK506 binding protein 5]). However, the …

Left atrial remodeling mechanisms associated with atrial fibrillation

D Qiu, L Peng, DN Ghista, KKL Wong - Cardiovascular Engineering and …, 2021 - Springer
Heart disease has always been one of the important diseases that endanger health and
cause death. Therefore, it is particularly important to understand left atrium reconstruction …

Murine electrophysiological models of cardiac arrhythmogenesis

CLH Huang - Physiological reviews, 2017 - journals.physiology.org
Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …

[HTML][HTML] A biological rationale for the disparate effects of omega-3 fatty acids on cardiovascular disease outcomes

SCR Sherratt, P Libby, DL Bhatt, RP Mason - … , Leukotrienes and Essential …, 2022 - Elsevier
The omega-3 fatty acids (n3-FAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid
(DHA) rapidly incorporate into cell membranes where they modulate signal transduction …