Since their discovery in the late 1980s, neonicotinoid pesticides have become the most
widely used class of insecticides worldwide, with large-scale applications ranging from plant …

Modern agricultural chemistry has to support farmers by providing innovative agrochemicals.
In this context, the introduction of sulfur atoms into an active ingredient is still an important …

Sulfoximines have been largely disregarded in medicinal chemistry for a long time.
However, recently, they have risen to the apparent level of stardom on the drug discovery …

Neonicotinoids have been used to protect crops and animals from insect pests since the
1990s, but there are concerns regarding their adverse effects on nontarget organisms …

Systemic insecticides, such as neonicotinoids, are a major contributor towards beneficial
insect declines. This has led to bans and restrictions on neonicotinoid use globally, most …

The design of bioisosteres represents a creative and productive approach to improve a
molecule, including by enhancing potency, addressing pharmacokinetic challenges …

Sulfoximines, the next generation systemic insecticides developed to replace
neonicotinoids, have been shown to negatively impact pollinator development and …

Neonicotinoids (neonics) are remarkably effective as plant systemics to control sucking
insects and for flea control on dogs and cats. The nitroimines imidacloprid, clothianidin …

BACKGROUND The development and commercialisation of new chemical classes of
insecticides for efficient crop protection measures against destructive invertebrate pests is of …

Climate change and agricultural intensification are exposing insect pollinators to
temperature extremes and increasing pesticide usage. Yet, we lack good quantification of …