Tumor suppressor genes cooperate with each other in tumors. Three important tumor
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …

Cancer can be identified as a chaotic cell state, which breaks the rules that govern growth
and reproduction, with main characteristics such as uncontrolled division, invading other …

Ischemic stroke (IS) is a multifactorial and heterogeneous neurological disorder with high
rate of death and long-term impairment. Despite years of studies, there are still no stroke …

In cancerous cells, significant changes occur in the activity of signaling pathways affecting a
wide range of cellular activities ranging from growth and proliferation to apoptosis …

The p53 tumor suppressor plays a major role in controlling the initiation and development of
cancer by regulating cell cycle arrest, apoptosis, senescence, and DNA repair. The MDM2 …

Any alteration at the genetic or epigenetic level, may result in multiplex of diseases including
tumorigenesis which ultimately results in the cancer development. Restoration of the normal …

The assembly of stress granules (SGs) is a well-known cellular strategy for reducing stress-
related damage and promoting cell survival. SGs have become important players in human …

Mycosis fungoides (MF) is a slowly progressive cutaneous T-cell lymphoma (CTCL) for
which there is no cure. In the early plaque stage, the disease is indolent, but development of …

Abstract The Activator Protein 2 (AP-2) transcription factor (TF) family is vital for the
regulation of gene expression during early development as well as carcinogenesis process …

The mutant protein FOXL2C134W is expressed in at least 95% of adult-type ovarian
granulosa cell tumors (AGCT) and is considered to be a driver of oncogenesis in this …