Abstract Serotonin (5-HT) is known to play a critical role in regulation of essential neural
processes, whereas more recent research highlights serotonin's modulatory effects on …

Exposure to chronic stress contributes considerably to the development of cognitive
impairments in psychiatric disorders such as depression, generalized anxiety disorder …

Cross-species studies have identified an evolutionarily conserved role for serotonin in
flexible behavior including reversal learning. The aim of the current study was to investigate …

Cognitive flexibility is a prefrontal cortex-dependent neurocognitive process that enables
behavioral adaptation in response to changes in environmental contingencies. Electrical …

During development, genetic and environmental factors interact to modify specific
phenotypes. Both in humans and in animal models, early adversities influence cognitive …

The orbital cortex (ORB) of the rat consists of five divisions: the medial (MO), ventral (VO),
ventrolateral (VLO), lateral (LO), and dorsolateral (DLO) orbital cortices. No previous report …

Objectives We investigated the effects of 5-HT 2A receptor (5-HT 2A R) and 5-HT 2C
receptor (5-HT 2C R) antagonism on flexibility and underlying RL mechanisms. Methods …

Open access to rodent cognitive data has lagged behind the rapid generation of large open-
access datasets in other areas of neuroscience, such as neuroimaging and genomics. One …

The current special issue on fronto-executive functions highlights a diverse collection of
papers that revisited, in various ways, scientific reports that originated in the 1950s to …

Cognitive flexibility, the ability to adapt behavior in response to a changing environment, is
disrupted in several neuropsychiatric disorders, including obsessive–compulsive disorder …