More than 1 out of 10 women worldwide are diagnosed with polycystic ovary syndrome
(PCOS), the leading cause of female reproductive and metabolic dysfunction. Despite its …

Introduction: Polycystic ovary syndrome (PCOS) diagnosis comprises combinations of
female hyperandrogenism, menstrual irregularity and polycystic ovaries. While it is a familial …

Androgen and its receptor (AR) play a critical role in reproductive function under both
physiological and pathophysiological conditions. Female AR global knockout mice are …

Polycystic ovary syndrome (PCOS) is one of the major endocrine disorders affecting women
of reproductive age. Its etiology remains unclear. It is suggested that environmental factors …

Polycystic ovary syndrome (PCOS) is a common cause of female infertility.
Hyperandrogenism is both a major symptom and key diagnostic trait of PCOS; however, the …

In utero androgen excess reliably induces polycystic ovary syndrome (PCOS)-like
reproductive and metabolic traits in female monkeys, sheep, rats, and mice. In humans …

Genetics-based studies of women with polycystic ovary syndrome (PCOS) implicate> 20
PCOS risk genes that collectively account for 90% of PCOS cases. Animal models …

The pathophysiological mechanisms underlying the origin of several ovarian pathologies
remain unclear. In addition to the genetic basis, developmental insults are gaining attention …

Developmental programming refers to processes that occur during early life that may have
long‐term consequences, modulating adult health and disease. Complex diseases, such as …

Prenatal testosterone (T) excess, partly via androgenic programming, enhances follicular
recruitment/persistence in sheep as in women with polycystic ovarian syndrome (PCOS) …