The FOXO family of transcription factors: key molecular players in gastric cancer

Y Liu, X Ao, Y Jia, X Li, Y Wang, J Wang - Journal of Molecular Medicine, 2022 - Springer
Gastric cancer (GC) is the fifth most frequently diagnosed cancer worldwide and the third
leading cause of cancer-related death with an oncological origin. Despite its decline in …

Targeting long non-coding RNA to therapeutically regulate gene expression in cancer

D Fu, Y Shi, JB Liu, TM Wu, CY Jia, HQ Yang… - … Therapy-Nucleic Acids, 2020 - cell.com
Long-chain non-coding RNAs (lncRNAs) are RNA molecules with a length greater than 200
nt and no function of encoding proteins. lncRNAs play a precise regulatory function at …

A human mucosal melanoma organoid platform for modeling tumor heterogeneity and exploring immunotherapy combination options

L Sun, X Kang, H Ju, C Wang, G Yang, R Wang… - Science …, 2023 - science.org
Mucosal melanoma (MM), an aggressive rare subtype of melanoma, is distinct from
cutaneous melanoma and has poor prognoses. We addressed the lack of cell models for …

[HTML][HTML] The complex network of transcription factors, immune checkpoint inhibitors and stemness features in colorectal cancer: A recent update

M Merhi, F Ahmad, N Taib, V Inchakalody… - Seminars in Cancer …, 2023 - Elsevier
Cancer immunity is regulated by several mechanisms that include co-stimulatory and/or co-
inhibitory molecules known as immune checkpoints expressed by the immune cells. In …

Periostin deficiency reduces PD-1+ tumor-associated macrophage infiltration and enhances anti-PD-1 efficacy in colorectal cancer

T Wei, K Wang, S Liu, Y Fang, Z Hong, Y Liu, H Zhang… - Cell Reports, 2023 - cell.com
Periostin, a multifunctional extracellular protein, plays an important role in inflammatory
disorders and tumorigenesis. Our previous work has demonstrated that periostin deficiency …

Toward a mechanistic understanding of DNA binding by forkhead transcription factors and its perturbation by pathogenic mutations

S Dai, L Qu, J Li, Y Chen - Nucleic acids research, 2021 - academic.oup.com
Forkhead box (FOX) proteins are an evolutionarily conserved family of transcription factors
that play numerous regulatory roles in eukaryotes during developmental and adult life …

Circular RNA circCTNNA1 promotes colorectal cancer progression by sponging miR-149-5p and regulating FOXM1 expression

P Chen, Y Yao, N Yang, L Gong, Y Kong, A Wu - Cell death & disease, 2020 - nature.com
Circular RNAs (circRNAs) are an emerging class of non-coding RNAs, identified to
participate in multiple malignancies. Nevertheless, the clinical significance, biological …

Heat shock proteins and cancer: The FoxM1 connection

Z Alimardan, M Abbasi, F Hasanzadeh… - Biochemical …, 2023 - Elsevier
Heat shock proteins (Hsp) and FoxM1 have significant roles in carcinogenesis. According to
their relative molecular weight, Hsps are divided into Hsp110, Hsp90, Hsp70, Hsp60 …

PVT1 Long Non-coding RNA in Gastrointestinal Cancer

Á Martínez-Barriocanal, D Arango, H Dopeso - Frontiers in Oncology, 2020 - frontiersin.org
Whole genome and transcriptome sequencing technologies have led to the identification of
many long non-coding RNAs (lncRNAs) and stimulated the research of their role in health …

Recent Advances in Transcription Factors Biomarkers and Targeted Therapies Focusing on Epithelial–Mesenchymal Transition

KT Chuang, SS Chiou, SH Hsu - Cancers, 2023 - mdpi.com
Simple Summary The study discusses the potential of targeting transcription factors (TFs) for
cancer therapy and provide a systematic classification of various types of TFs involved in the …