Infection and atherosclerosis: TLR-dependent pathways

B Li, Y Xia, B Hu - Cellular and Molecular Life Sciences, 2020 - Springer
Atherosclerotic vascular disease (ASVD) is a chronic process, with a progressive course
over many years, but it can cause acute clinical events, including acute coronary syndromes …

Host genetics of cytomegalovirus pathogenesis

E Sezgin, P An, CA Winkler - Frontiers in genetics, 2019 - frontiersin.org
Human cytomegalovirus (HCMV) is a ubiquitous herpes virus (human herpes virus 5) with
the highest morbidity and mortality rates compared to other herpes viruses. Risk groups …

TLR4 896A/G and TLR9 1174G/A polymorphisms are associated with the risk of infectious mononucleosis

A Jabłońska, M Studzińska, L Szenborn… - Scientific reports, 2020 - nature.com
Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns and activate
innate and adaptive immune responses. Single nucleotide polymorphisms (SNPs) within the …

[PDF][PDF] Epidemiology of Cytomegalovirus among pregnant women in Africa

D Mhandire, S Rowland-Jones, K Mhandire… - Journal of infection in …, 2019 - ora.ox.ac.uk
Abstract Introduction: Vertical transmission of Cytomegalovirus (CMV), resulting in
congenital CMV (cCMV) infection could have disabling and potentially fatal effects on the …

TLR9 -1486T/C and 2848C/T SNPs Are Associated with Human Cytomegalovirus Infection in Infants

E Paradowska, A Jabłońska, M Studzińska… - PLoS …, 2016 - journals.plos.org
Toll-like receptor 9 (TLR9) recognizes non-methylated viral CpG-containing DNA and serves
as a pattern recognition receptor that signals the presence of human cytomegalovirus …

Association of TLR3 L412F Polymorphism with Cytomegalovirus Infection in Children

M Studzińska, A Jabłońska, M Wiśniewska-Ligier… - PLoS …, 2017 - journals.plos.org
Intracellular Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA (dsRNA) and
activates antiviral immune responses through the production of type I interferons (IFNs) and …

Predictors of severity for postnatal cytomegalovirus infection in preterm infants and implications for treatment

J Gunkel, TFW Wolfs, LS de Vries… - Expert review of anti …, 2014 - Taylor & Francis
Postnatal cytomegalovirus (CMV) infection is common in neonates and is mostly acquired
through infected breast milk from seropositive mothers. In this review, risk factors of postnatal …

Germline genetic variants of viral entry and innate immunity may influence susceptibility to SARS-CoV-2 infection: toward a polygenic risk score for risk stratification

VK Grolmusz, A Bozsik, J Papp, A Patócs - Frontiers in Immunology, 2021 - frontiersin.org
The ongoing COVID-19 pandemic caused by the novel coronavirus, SARS-CoV-2 has
affected all aspects of human society with a special focus on healthcare. Although older …

Ethnicity-dependent influence of innate immune genetic markers on morphine PCA requirements and adverse effects in postoperative pain

AA Somogyi, AT Sia, EC Tan, JK Coller… - Pain, 2016 - journals.lww.com
Although several genetic factors have been associated with postsurgical morphine
requirements, those involving the innate immune system and cytokines have not been well …

Vaccine development for cytomegalovirus

N Inoue, M Abe, R Kobayashi, S Yamada - Human herpesviruses, 2018 - Springer
The development of a cytomegalovirus (CMV) vaccine has become a top priority due to its
potential cost-effectiveness and associated public health benefits. However, there are a …