Pluripotency defines the propensity of a cell to differentiate into, and generate, all somatic,
as well as germ cells. The epiblast of the early mammalian embryo is the founder population …

Melanoma is one of the most lethal neoplasms of the skin. Despite the revolutionary
introduction of immune checkpoint inhibitors, metastatic spread, and recurrence remain …

Age-associated cardiovascular diseases are at least partially ascribable to vascular cell
senescence. Replicative senescence (RS) and stress-induced premature senescence …

Infantile hemangioma (IH) is the most prevalent type of vascular tumor in infants. The
pathophysiology of IH is unknown. The tissue structure and physiology of two-dimensional …

The Shc family of adaptor proteins is a group of proteins that lacks intrinsic enzymatic
activity. Instead, Shc proteins possess various domains that allow them to recruit different …

Metastatic melanoma accounts for approximately 80% of skin cancer-related deaths. Up to
now there has been no effective treatment for stage IV melanoma patients due to the …

Circulating tumour cell (CTC) behaviours are distinct from those of bulk tissues. Thus,
treatments to eliminate CTCs differ from the regimens followed to reduce the primary tumour …

Proto-oncogenic Src homology and collagen (Shc) proteins have been considered
archetypal adaptors of epidermal growth factor receptor (EGFR)–mediated signaling. We …

Abstract Background The Src homology and collagen 4 (SHC4) is an important intracellular
adaptor protein that has been shown to play a pro-cancer role in melanoma and glioma …

Although the broad and unique differentiation potential of pluripotent stem cells relies on a
complex transcriptional network centered around Oct4, Sox2, and Nanog, two well-distinct …