Brain-derived neurotrophic factor (BDNF) is the most abundant neurotrophin in the adult
brain and functions as both a primary neurotrophic signal and a neuromodulator. It serves …

Orofacial pain represents a multidisciplinary biomedical challenge involving basic and
clinical research for which no satisfactory solution has been found. In this regard, trigeminal …

Pseudorabies virus (PRV) infection can elicit nervous system disorders. Curcumin has been
reported to have neuroprotective effects. However, whether curcumin can protect neurons …

Objective This review aims to systematically summarize the methods of establishing various
models of trigeminal neuralgia (TN), the scope of application, and current animals used in …

This review highlights potential molecular targets for treating neuropathic orofacial pain
based on current findings in animal models. Preclinical research is currently elucidating the …

Trigeminal neuralgia (TN), a sudden, needle-like pain in the distribution area of the
trigeminal nerve, can seriously affect the physical and mental health of patients. In chronic …

Background: Trigeminal neuralgia (TN) is the most common neuropathic disorder in the
maxillofacial region. The etiology and pathogenesis of TN have not been clearly determined …

The trigeminal root entry zone is the zone at which the myelination switches from peripheral
Schwann cells to central oligodendrocytes. Its special anatomical and physiological …

Microvascular compression of the trigeminal root entry zone (TREZ) is the main cause of
most primary trigeminal neuralgia (TN), change of glial plasticity was previously studied in …

Introduction The aim of this study was to investigate the effect and possible mechanisms of
the blood-nerve barrier (BNB) and the coagulation-anticoagulation system in modulating the …