The effect of the bacterial heat-stable nucleoid-structuring (H-NS) protein on gene
expression is overwhelmingly negative and extends throughout the genome, pointing to an …

The bacterial chromosomal DNA is folded into a compact structure called nucleoid. The
shape and size of this 'body'is determined by a number of factors. Major players are DNA …

Ribosomal RNA (rRNA) transcription is regulated primarily at the level of initiation from rRNA
promoters. The unusual kinetic properties of these promoters result in their specific …

Inheritable bacterial defence systems against phage infection and foreign DNA, termed
CRISPR (clustered regularly interspaced short palindromic repeats), consist of cas protein …

The recently discovered prokaryotic CRISPR/Cas defence system provides immunity against
viral infections and plasmid conjugation. It has been demonstrated that in Escherichia coli …

▪ Abstract Ribosomal RNA transcription is the rate-limiting step in ribosome synthesis in
bacteria and has been investigated intensely for over half a century. Multiple mechanisms …

The H-NS nucleoid-associated DNA-binding protein is an important global repressor of
transcription in Gram-negative bacteria. Recently, H-NS has been implicated in the process …

In Escherichia coli crosstalk between DNA supercoiling, nucleoid-associated proteins and
major RNA polymerase σ initiation factors regulates growth phase-dependent gene …

Genome architecture has proven to be critical in determining gene regulation across almost
all domains of life. While many of the key components and mechanisms of eukaryotic …

The control of ribosomal RNA transcription is one of the most enduring issues in molecular
microbiology, having been subjected to intense scrutiny for over 50 years. Rapid changes in …