[HTML][HTML] Gut microbiome and health: mechanistic insights

WM De Vos, H Tilg, M Van Hul, PD Cani - Gut, 2022 - gut.bmj.com
The gut microbiota is now considered as one of the key elements contributing to the
regulation of host health. Virtually all our body sites are colonised by microbes suggesting …

Microbiota and maintenance of skin barrier function

TA Harris-Tryon, EA Grice - Science, 2022 - science.org
Human skin forms a protective barrier against the external environment and is our first line of
defense against toxic, solar, and pathogenic insults. Our skin also defines our outward …

Staphylococcus epidermidis and its dual lifestyle in skin health and infection

MM Severn, AR Horswill - Nature Reviews Microbiology, 2023 - nature.com
The coagulase-negative bacterium Staphylococcus epidermidis is a member of the human
skin microbiota. S. epidermidis is not merely a passive resident on skin but actively primes …

Skin barrier function and the microbiome

HJ Lee, M Kim - International journal of molecular sciences, 2022 - mdpi.com
Human skin is the largest organ and serves as the first line of defense against environmental
factors. The human microbiota is defined as the total microbial community that coexists in the …

Mining for encrypted peptide antibiotics in the human proteome

MDT Torres, MCR Melo, L Flowers… - Nature Biomedical …, 2022 - nature.com
The emergence of drug-resistant bacteria calls for the discovery of new antibiotics. Yet, for
decades, traditional discovery strategies have not yielded new classes of antimicrobial …

Psoriatic arthritis from a mechanistic perspective

G Schett, P Rahman, C Ritchlin, IB McInnes… - Nature Reviews …, 2022 - nature.com
Psoriatic arthritis (PsA) is part of a group of closely related clinical phenotypes ('psoriatic
disease') that is defined by shared molecular pathogenesis resulting in excessive …

Immune regulation through tryptophan metabolism

SK Seo, B Kwon - Experimental & Molecular Medicine, 2023 - nature.com
Amino acids are fundamental units of molecular components that are essential for sustaining
life; however, their metabolism is closely interconnected to the control systems of cell …

Role of AHR ligands in skin homeostasis and cutaneous inflammation

N Fernández-Gallego, F Sánchez-Madrid, D Cibrian - Cells, 2021 - mdpi.com
Aryl hydrocarbon receptor (AHR) is an important regulator of skin barrier function. It also
controls immune-mediated skin responses. The AHR modulates various physiological …

The skin microbiome: current landscape and future opportunities

P Smythe, HN Wilkinson - International journal of molecular sciences, 2023 - mdpi.com
Our skin is the largest organ of the body, serving as an important barrier against the harsh
extrinsic environment. Alongside preventing desiccation, chemical damage and …

The wound microbiota: microbial mechanisms of impaired wound healing and infection

A Uberoi, A McCready-Vangi, EA Grice - Nature Reviews Microbiology, 2024 - nature.com
The skin barrier protects the human body from invasion by exogenous and pathogenic
microorganisms. A breach in this barrier exposes the underlying tissue to microbial …