The melanocortins (MC) can affect interscapular brown adipose tissue (IBAT) thermogenesis
via its sympathetic nervous system (SNS) innervation. We chose a site of high MC4-receptor …

Abstract Knowledge of specific neurotransmitters as well as the pathways and mechanisms
regulating appetite in ruminants that continually graze, such as sheep, is incomplete …

To address whether defective melanocortin activation is one element of leptin resistance
with age, we infused centrally the melanocortin agonist, MTII and antagonist, SHU9119 in …

Objective The central melanocortin system is essential for the regulation of food intake and
body weight. Agouti-related protein (AgRP) is the sole orexigenic component of the central …

Regulation of energy balance consists of two intertwined circuitries: food intake-metabolic
rate-body weight, vs. metabolic rate-heat loss-body temperature. Metabolic rate serves …

Changes of the anorexigenic and hypermetabolic components of the overall catabolic effect
of alpha-MSH were studied in rats as a function of age. In male Wistar rats a 7day-long …

Childhood overweight and obesity have reached epidemic proportions worldwide, and the
increase in weightassociated co-morbidities including premature type 2 diabetes mellitus …

Over the past decade, a potential sixth taste, fat taste (“oleogustus”), has been identified.
Studies in adults and children of various ethnicities have demonstrated that both lifestyle …

Development of the adrenal cortex is dependent upon the specific regulation of cellular
proliferation and differentiation. Although both intra-adrenal transcription factors and extra …

The central melanocortin system is composed of neurons that express either the
proopiomelanocortin (POMC) or the agouti-related protein (AgRP). POMC is cleaved in …