Chemistry, traditionally being the science of synthesis and structural manipulations of
molecules, has gradually undertaken the more challenging task of biology-oriented …

Stem cell factor (SCF) is a dimeric molecule that exerts its biological functions by binding to
and activating the receptor tyrosine kinase c-Kit. Activation of c-Kit leads to its …

Protein and lipid kinases play key regulatory roles in a number of biological processes.
Unsurprisingly, activating mutations in kinases have been linked to a number of disorders …

In the early 2000s, the anticancer drug imatinib (Glivec®) appeared on the market, exhibiting
a new mode of action by selective kinase inhibition. Consequently, kinases became a …

Botanical drugs based on Artemisia annua L.(Asteraceae) are important in the treatment of
malaria. Alongside with artemisinin, this aromatic species produces high and variable …

c-Src and c-Abl are two closely related protein kinases that constitute important anticancer
targets. Despite their high sequence identity, they show different sensitivities to the …

Janus kinases (JAK), a group of proteins in the nonreceptor tyrosine kinase (NRTKs) family,
play a crucial role in growth, survival, and angiogenesis. They are activated by cytokines …

Abstract Cyclin Dependent Kinases CDKs unpredictable activity has been accounted for a
wide assortment of human malignancies, so it might be conceivable to design …

The design, synthesis and biological evaluations of fourteen 4-substituted 2, 6-dimethylfuro
[2, 3-d] pyrimidines are reported. Four compounds (11–13, 15) inhibit vascular endothelial …

Kinase enrichment utilizing broad-spectrum kinase inhibitors enables the identification of
large proportions of the expressed kinome by mass spectrometry. However, the existing …