The sugar alcohol erythritol is a relatively new food ingredient. It is naturally occurring in
plants, however, produced commercially by fermentation. It is also produced endogenously …

We are in the midst of a shift in biological research paradigms from reductionist
methodologies that generate a hypothesis and rigorously and quantitatively measure the …

Artificial sweeteners are widely used sugar substitutes, but little is known about their long-
term effects on cardiometabolic disease risks. Here we examined the commonly used sugar …

To identify metabolomic reprogramming in early hyperlipidemia, unbiased metabolome was
screened in four tissues from ApoE−/− mice fed with high fat diet (HFD) for 3 weeks. 30, 122 …

Importance African American individuals have disproportionate rates of coronary heart
disease (CHD) but lower levels of coronary artery calcium (CAC), a marker of subclinical …

The circulating proteome offers insights into the biological pathways that underlie disease.
Here, we test relationships between 1,468 Olink protein levels and the incidence of 23 age …

Background Elevated serum erythritol concentration is a predictive biomarker of diabetes
and cardiovascular incidence and complications. Erythritol is synthesized endogenously …

Abstract Purpose of Review We review the limitations of current approaches for predicting
Coronary Artery Disease (CAD) in young adults and explore the alternative approaches …

Chronic obstructive pulmonary disease (COPD) is a disease with marked metabolic
disturbance. Previous studies have shown the association between single metabolites and …

Background We aimed to evaluate the impacts of metabolomic body mass index (metBMI)
phenotypes on the risks of cardiovascular and ocular diseases outcomes. Methods This …