1928 Circulation October 22, 2013 mental health, functional status, activity limitations,
cancerrelated pain, and cancer-related anxiety) declined moderately to severely in 44%. 5 …

Objectives Siblings' psychosocial adjustment to childhood cancer is poorly understood. This
systematic review summarizes findings and limitations of the sibling literature since 2008 …

Cancer diagnostics and therapies have improved steadily over the last few decades,
markedly increasing life expectancy for patients at all ages. However, conventional and …

Background Doxorubicin chemotherapy is associated with cardiomyopathy. Dexrazoxane
reduces cardiac damage during treatment with doxorubicin in children with acute …

Opinion statement Anthracyclines have been widely used in children and adults to treat
hematologic malignancies, soft-tissue sarcomas, and solid tumors. However, anthracyclines …

Abstract Treatment advances and higher participation rates in clinical trials have rapidly
increased the number of survivors of childhood cancer. However, chemotherapy and …

Purpose To determine whether cardiovascular abnormalities in childhood cancer survivors
are restricted to patients exposed to cardiotoxic anthracyclines and cardiac irradiation and …

Anthracycline chemotherapeutic agents are widely used to treat childhood cancers, helping
to create an increasing population of childhood cancer survivors. Cardiac complications can …

Advances in cancer treatment have greatly improved survival rates of children with cancer.
However, these same chemotherapeutic or radiologic treatments may result in long-term …

Treatment advances have increased survival in children with cancer, but subclinical,
progressive, irreversible, and sometimes fatal treatment-related cardiovascular effects may …