Using Drosophila melanogaster as a suitable platform for drug discovery from natural products in inflammatory bowel disease

M Xiu, Y Wang, D Yang, X Zhang, Y Dai… - Frontiers in …, 2022 - frontiersin.org
Inflammatory bowel disease (IBD) is a chronic and life-treating inflammatory disease that
can occur in multiple parts of the human intestine and has become a worldwide problem …

Ameliorative effects of L-theanine on dextran sulfate sodium induced colitis in C57BL/6J mice are associated with the inhibition of inflammatory responses and …

D Wang, M Cai, T Wang, T Liu, J Huang, Y Wang… - Food Research …, 2020 - Elsevier
This study investigated the effects of L-theanine supplementation on the colonic mucosa
injury in C57BL/6J male mice treated with dextran sulfate sodium (DSS)-induced colitis …

The communication between intestinal microbiota and ulcerative colitis: an exploration of pathogenesis, animal models, and potential therapeutic strategies

Y Hu, Z Ye, M Wu, Y She, L Li, Y Xu, K Qin, Z Hu… - Frontiers in …, 2021 - frontiersin.org
Ulcerative Colitis (UC) is a chronic inflammatory bowel disease. The prolonged course of
UC and the lack of effective treatment management make it difficult to cure, affecting the …

Lactiplantibacillus plantarum HY7718 Improves Intestinal Integrity in a DSS-Induced Ulcerative Colitis Mouse Model by Suppressing Inflammation through Modulation …

HJ Kim, HJ Jeon, JY Kim, JJ Shim, JH Lee - International Journal of …, 2024 - mdpi.com
Inflammatory bowel disease (IBD), a chronic condition that causes persistent inflammation in
the digestive system, is closely associated with the intestinal microbiome. Here, we …

The microbiota-gut-brain axis: Focus on the fundamental communication pathways

M Bistoletti, A Bosi, D Banfi, C Giaroni, A Baj - Progress in molecular …, 2020 - Elsevier
The existence of a bidirectional communication system termed the “gut-brain axis” linking
the gastrointestinal tract with the brain has been recognized since the nineteenth century. In …

Natural flavone tricin exerted anti-inflammatory activity in macrophage via NF-κB pathway and ameliorated acute colitis in mice

XX Li, SG Chen, GGL Yue, HF Kwok, JKM Lee… - Phytomedicine, 2021 - Elsevier
Background Ulcerative colitis is a subtype of inflammatory bowel disease, characterized by
relapsing inflammation in the gastrointestinal tract with limited treatment options. Previous …

E3 ligase RNF99 negatively regulates TLR-mediated inflammatory immune response via K48-linked ubiquitination of TAB2

J Zhang, L Cao, A Gao, R Ren, L Yu, Q Li… - Cell Death & …, 2023 - nature.com
Innate immunity is the first line to defend against pathogenic microorganisms, and Toll-like
receptor (TLR)-mediated inflammatory responses are an essential component of innate …

Role of PD-L1 in gut mucosa tolerance and chronic inflammation

M Chulkina, EJ Beswick, IV Pinchuk - International journal of molecular …, 2020 - mdpi.com
The gastrointestinal (GI) mucosa is among the most complex systems in the body. It has a
diverse commensal microbiome challenged continuously by food and microbial components …

Transcriptional signatures that define ulcerative colitis in remission

CG Fenton, H Taman, J Florholmen… - Inflammatory bowel …, 2021 - academic.oup.com
Background This study addresses whether existing specific transcriptional profiles can
improve and support the current status of the definition of ulcerative colitis (UC) remission …

The impact of the microbiome on resistance to cancer treatment with chemotherapeutic agents and immunotherapy

A Sevcikova, N Izoldova, V Stevurkova… - International Journal of …, 2022 - mdpi.com
Understanding the mechanisms of resistance to therapy in human cancer cells has become
a multifaceted limiting factor to achieving optimal cures in cancer patients. Besides genetic …