Expansion and activation of fibroblasts following cardiac injury is important for repair but
may also contribute to fibrosis, remodeling, and dysfunction. The authors discuss the …

Myocardial infarction triggers an intense inflammatory response that is essential for cardiac
repair, but which is also implicated in the pathogenesis of postinfarction remodelling and …

Environmental factors are the largest contributors to cardiovascular disease. Here we show
that cardiac organoids that incorporate an oxygen-diffusion gradient and that are stimulated …

Cardiac myofibroblasts play an important role in myocardial remodeling. Although α-smooth
muscle actin (α-SMA) expression is the hallmark of mature myofibroblasts, its role in …

Myocardial fibrosis refers to a variety of quantitative and qualitative changes in the interstitial
myocardial collagen network that occur in response to cardiac ischaemic insults, systemic …

Cardiac fibrosis is characterized by net accumulation of extracellular matrix proteins in the
cardiac interstitium, and contributes to both systolic and diastolic dysfunction in many …

Cardiac fibrosis remains an important health concern, but the study of fibroblast biology has
been hindered by a lack of effective means for identifying and tracking fibroblasts. Recent …

Rationale: Healing after myocardial infarction involves the biphasic accumulation of
inflammatory lymphocyte antigen 6C (Ly-6C) high and reparative Ly-6Clow monocytes …

Elevated levels of circulating pro‐inflammatory biomarkers in patients with both ischaemic
and non‐ischaemic heart failure (HF) correlate with disease severity and prognosis …

Purpose: Both cardiomyocytes and cardiac fibroblasts (CF) play essential roles in cardiac
development, function, and remodeling. Properties of 3D co-cultures are incompletely …