[HTML][HTML] Kupffer cells: inflammation pathways and cell-cell interactions in alcohol-associated liver disease

E Slevin, L Baiocchi, N Wu, B Ekser, K Sato… - The American Journal of …, 2020 - Elsevier
Chronic alcohol consumption is linked to the development of alcohol-associated liver
disease (ALD). This disease is characterized by a clinical spectrum ranging from steatosis to …

MicroRNA-223 ameliorates alcoholic liver injury by inhibiting the IL-6–p47phox–oxidative stress pathway in neutrophils

M Li, Y He, Z Zhou, T Ramirez, Y Gao, Y Gao, RA Ross… - Gut, 2017 - gut.bmj.com
Objectives Chronic-plus-binge ethanol feeding activates neutrophils and exacerbates liver
injury in mice. This study investigates how recent excessive drinking affects peripheral …

Pathogenic mechanisms and regulatory factors involved in alcoholic liver disease

C Yan, W Hu, J Tu, J Li, Q Liang, S Han - Journal of Translational …, 2023 - Springer
Alcoholism is a widespread and damaging behaviour of people throughout the world. Long-
term alcohol consumption has resulted in alcoholic liver disease (ALD) being the leading …

Loss of hepatic DRP1 exacerbates alcoholic hepatitis by inducing megamitochondria and mitochondrial maladaptation

X Ma, A Chen, L Melo, A Clemente‐Sanchez… - Hepatology, 2023 - journals.lww.com
Loss of hepatic DRP1 exacerbates alcoholic hepatitis by indu... : Hepatology Loss of hepatic
DRP1 exacerbates alcoholic hepatitis by inducing megamitochondria and mitochondrial …

Structure and hepatoprotective activity of Usp10/NF-κB/Nrf2 pathway-related Morchella esculenta polysaccharide

S Teng, Y Zhang, X Jin, Y Zhu, L Li, X Huang… - Carbohydrate …, 2023 - Elsevier
The water-soluble Morchella esculenta polysaccharide 2 (MEP2) was purified and isolated
from an aqueous extract of the Morchella esculenta fruiting bodies. MEP2, having a …

[HTML][HTML] Antioxidant and anti-inflammatory agents in chronic liver diseases: Molecular mechanisms and therapy

CY Zhang, S Liu, M Yang - World Journal of Hepatology, 2023 - ncbi.nlm.nih.gov
Chronic liver disease (CLD) is a continuous process that causes a reduction of liver function
lasting more than six months. CLD includes alcoholic liver disease (ALD), non-alcoholic fatty …

[HTML][HTML] Alcoholic liver disease: A current molecular and clinical perspective

K Ohashi, M Pimienta, E Seki - Liver research, 2018 - Elsevier
Heavy alcohol use is the cause of alcoholic liver disease (ALD). The ALD spectrum ranges
from alcoholic steatosis to steatohepatitis, fibrosis, and cirrhosis. In Western countries …

Endoplasmic reticulum-targeted inhibition of CYP2E1 with vitamin E nanoemulsions alleviates hepatocyte oxidative stress and reverses alcoholic liver disease

Y Shi, Y Liu, S Wang, J Huang, Z Luo, M Jiang, Y Lu… - Biomaterials, 2022 - Elsevier
Alcoholic liver disease (ALD) is a global healthcare problem and socioeconomic issue that
is primarily driven by chronic and/or excessive alcohol consumption. Upon alcohol …

PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis

P Mukhopadhyay, B Horváth, M Rajesh, ZV Varga… - Journal of …, 2017 - Elsevier
Background & Aims Mitochondrial dysfunction, oxidative stress, inflammation, and metabolic
reprograming are crucial contributors to hepatic injury and subsequent liver fibrosis. Poly …

The genetics of alcohol dependence and alcohol-related liver disease

F Stickel, C Moreno, J Hampe, MY Morgan - Journal of hepatology, 2017 - Elsevier
The susceptibility to developing alcohol dependence and significant alcohol-related liver
injury is determined by a number of constitutional, environmental and genetic factors …