[HTML][HTML] Stress mechanism involved in the progression of alcoholic liver disease and the therapeutic efficacy of nanoparticles

H Aghara, P Chadha, D Zala, P Mandal - Frontiers in Immunology, 2023 - frontiersin.org
Alcoholic liver disease (ALD) poses a significant threat to human health, with excessive
alcohol intake disrupting the immunotolerant environment of the liver and initiating a …

Role and mechanisms of autophagy in alcohol-induced liver injury

X Chao, WX Ding - Advances in Pharmacology, 2019 - Elsevier
Alcoholic liver disease (ALD) is one of the major causes of chronic liver disease worldwide.
Currently, no successful treatments are available for ALD. The pathogenesis of ALD is …

Ameliorating the effect and mechanism of chitosan oligosaccharide on nonalcoholic fatty liver disease in mice

J Zhang, J Feng, Y Bai, Q Che, H Cao, J Guo, Z Su - Food & Function, 2023 - pubs.rsc.org
Previous studies have found that chitosan oligosaccharide (COST) can alleviate the clinical
symptoms in non-alcoholic fatty liver disease (NAFLD) patients. We intend to intervene with …

Alcohol induces hepatocytes necroptosis through the LC3/RIPK1/RIPK3 pathway

Y Chen, M Liu, H Wei, J Guo, S Zhang, X Bu… - Food and Chemical …, 2023 - Elsevier
Excessive alcohol consumption leads to serious liver injury. Necroptosis is a programmed
cell death form, which has been confirmed to be involved in alcoholic liver injury. However …

[HTML][HTML] Hyaluronic acid 35 normalizes TLR4 signaling in Kupffer cells from ethanol-fed rats via regulation of microRNA291b and its target Tollip

P Saikia, S Roychowdhury, D Bellos, KA Pollard… - Scientific reports, 2017 - nature.com
TLR4 signaling in hepatic macrophages is increased after chronic ethanol feeding.
Treatment of hepatic macrophages after chronic ethanol feeding with small-specific sized …

[HTML][HTML] Loss of hepatic transcription factor EB attenuates alcohol-associated liver carcinogenesis

X Chao, S Wang, M Hlobik, A Ballabio, HM Ni… - The American Journal of …, 2022 - Elsevier
Alcohol is a well-known risk factor for hepatocellular carcinoma. Autophagy plays a dual role
in liver cancer, as it suppresses tumor initiation and promotes tumor progression …

[HTML][HTML] JBB attenuates acute and chronic alcoholic liver injury by regulating the NFκB, KEAP1, and HIF1 pathways

Y Fu, Z Zeng, S Feng, Y Chen, Q Ding, Y Shi - Journal of Functional Foods, 2023 - Elsevier
Alcoholic liver disease (ALD) is a liver injury caused by chronic or binge alcohol
consumption. Jiubanban (JBB) is a 10-edible-herb-formula. The current study investigated …

[HTML][HTML] Role of the chemokine system in liver fibrosis: a narrative review

KL Poulsen, CK Cajigas-Du Ross… - Digestive medicine …, 2022 - ncbi.nlm.nih.gov
Methods: A comprehensive literature review was performed searching PubMed for relevant
English studies and texts regarding chemokine biology, chronic liver disease and liver …

PTTG1 alleviates acute alcoholic liver injury by inhibiting endoplasmic reticulum stress‐induced hepatocyte pyroptosis

S Tien, H Zhou, Q Zhou, H Liu, B Wu… - Liver International, 2023 - Wiley Online Library
Abstract Background & Aims Heavy drinking is a primary cause of alcoholic liver injury (ALI).
Pituitary tumour transforming gene 1 (PTTG1) is involved in the occurrence and …

[HTML][HTML] Mincle-GSDMD-mediated release of IL-1β small extracellular vesicles from hepatic macrophages in ethanol-induced liver injury

Q Zhang, W Liu, K Bulek, H Wang… - Hepatology …, 2023 - journals.lww.com
Background: Macrophage-inducible C-type lectin (Mincle) is expressed on hepatic
macrophages and senses ethanol (EtOH)-induced danger signals released from dying …