Role of mesencephalic astrocyte‐derived neurotrophic factor in alcohol‐induced liver injury

G Chhetri, Y Liang, J Shao, D Han… - Oxidative Medicine …, 2020 - Wiley Online Library
Consumption of alcohol in immoderate quantity induces endoplasmic reticulum (ER) stress
response (alcohol‐induced ER stress). Mesencephalic astrocyte‐derived neurotrophic factor …

[HTML][HTML] Molecular mechanisms of autophagy and implications in liver diseases

Y Wu, HWS Tan, JY Lin, HM Shen, H Wang, G Lu - Liver Research, 2023 - Elsevier
Autophagy is a highly conserved process in which cytosolic contents are degraded by the
lysosome, which plays an important role in energy and nutrient balance, and protein or …

Inhibition of HMGB1/TLR4 signaling pathway by digitoflavone: A potential therapeutic role in alcohol-associated liver disease

Y Shang, M Jiang, N Chen, XL Jiang… - Journal of Agricultural …, 2022 - ACS Publications
Digitoflavone (DG) is a natural flavonoid abundant in many fruits, vegetables, and medicinal
plants. We investigated whether DG inhibits lipid accumulation and inflammatory responses …

Light-to-moderate alcohol consumption is associated with increased risk of type 2 diabetes in individuals with nonalcoholic fatty liver disease: a nine-year cohort study

L Xu, J Xie, S Chen, Y Chen, H Yang… - Official journal of the …, 2020 - journals.lww.com
OBJECTIVE: This study explored the association between light-to-moderate alcohol
consumption (LMAC) and risk of type 2 diabetes mellitus (T2DM) in individuals with …

[HTML][HTML] Bacillus coagulans regulates gut microbiota and ameliorates the alcoholic-associated liver disease in mice

Z Liu, T Liu, Z Zhang, Y Fan - Frontiers in Microbiology, 2024 - frontiersin.org
Introduction Alcoholic-associated liver diseases (ALD) are now widespread issues
worldwide. Alcoholic-induced chronic dysbiosis of the gut microbiota is one of the factors in …

Protective effect of isoliquiritigenin against ethanol-induced hepatic steatosis by regulating the SIRT1-AMPK pathway

AY Na, EJ Yang, JM Jeon, SH Ki, KS Song… - Toxicological Research, 2018 - Springer
Ethanol-induced fat accumulation, the earliest and most common response of the liver to
ethanol exposure, may be involved in the pathogenesis of liver diseases. Isoliquiritigenin …

[HTML][HTML] ER disposal pathways in chronic liver disease: protective, pathogenic, and potential therapeutic targets

CC Duwaerts, JL Maiers - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
The endoplasmic reticulum is a central player in liver pathophysiology. Chronic injury to the
ER through increased lipid content, alcohol metabolism, or accumulation of misfolded …

A mini-review of the rodent models for alcoholic liver disease: shortcomings, application, and future prospects

SX Liu, YC Du, T Zeng - Toxicology Research, 2021 - academic.oup.com
Rodents are the most common models in studies of alcoholic liver disease (ALD). Although
several rodents ALD models have been established and multiple mechanisms have been …

Natural products, extracts and formulations comprehensive therapy for the improvement of motor function in alcoholic liver disease

S Hu, S Li, Q Yan, X Hu, L Li, H Zhou, L Pan, J Li… - Pharmacological …, 2019 - Elsevier
Alcoholic liver disease (ALD) is a major cause of chronic liver disease worldwide that afflicts
human health. With the in-depth study of the disease, its pathogenesis has gradually …

[PDF][PDF] Development of capsular fibrosis beneath the liver surface in humans and mice

S Balog, Y Li, T Ogawa, T Miki, T Saito, SW French… - …, 2020 - Wiley Online Library
Glisson's capsule is the connective tissue present in the portal triad as well as beneath the
liver surface. Little is known about how Glisson's capsule changes its structure in capsular …