[HTML][HTML] Epilepsy: Mitochondrial connections to the 'Sacred'disease

WH Moos, DV Faller, IP Glavas, I Kanara, K Kodukula… - Mitochondrion, 2023 - Elsevier
Over 65 million people suffer from recurrent, unprovoked seizures. The lack of validated
biomarkers specific for myriad forms of epilepsy makes diagnosis challenging. Diagnosis …

Fast ripples reflect increased excitability that primes epileptiform spikes

SA Weiss, I Fried, J Engel Jr, MR Sperling… - Brain …, 2023 - academic.oup.com
The neuronal circuit disturbances that drive inter-ictal and ictal epileptiform discharges
remain elusive. Using a combination of extra-operative macro-electrode and micro-electrode …

Neuronal synchrony and critical bistability: Mechanistic biomarkers for localizing the epileptogenic network

SH Wang, G Arnulfo, L Nobili, V Myrov, P Ferrari… - …, 2024 - Wiley Online Library
Objective Postsurgical seizure freedom in drug‐resistant epilepsy (DRE) patients varies from
30% to 80%, implying that in many cases the current approaches fail to fully map the …

New vistas for epileptogenic zone (EZ) localization and interpretation

SH Wang, G Arnulfo, L Nobili, V Myrov, P Ferrari… - bioRxiv, 2023 - biorxiv.org
Drug resistant epilepsy (DRE) accounts for 30− 40% of all diagnosed cases of epilepsy. To
date, surgical disruption of the epileptogenic zone (EZ) is the most effective treatment for …

[PDF][PDF] BRAIN COMMUNICATIONS

SA Weiss, I Fried, J Engel Jr, MR Sperling, RKS Wong… - 2023 - researchgate.net
Spontaneous inter-ictal epileptiform spikes (ie spikes) were first recognized nearly a century
ago in extracellular recordings from animals exposed to chemoconvulsants and in the EEG …