Muscular dystrophies are a heterogeneous group of genetic diseases, characterized by
progressive degeneration of skeletal and cardiac muscle. Despite the intense investigation …

Several recent studies suggest the isolation of stem cells in skeletal muscle, but the
functional properties of these muscle-derived stem cells is still unclear. In the present study …

Muscle stem cells (MuSCs, satellite cells) are the major contributor to muscle regeneration.
Like most adult stem cells, long-term expansion of MuSCs in vitro is difficult. The in vivo …

This protocol details a procedure, known as the modified preplate technique, which is
currently used in our laboratory to isolate muscle cells on the basis of selective adhesion to …

Muscular dystrophies are a group of genetic muscle disorders that cause progressive
muscle weakness and degeneration. Within this group, Duchenne muscular dystrophy …

Myoblasts, the precursors of skeletal muscle fibers, can be induced to withdraw from the cell
cycle and differentiate in vitro. Recent studies have also identified undifferentiated …

Duchenne muscular dystrophy (DMD) remains an intractable genetic disease. Althogh there
are several animal models of DMD, there is no human cell model that carries patient-specific …

Myoblast transplantation has been extensively studied as a gene complementation
approach for genetic diseases such as Duchenne Muscular Dystrophy. This approach has …

Little progress has been made toward the use of embryonic stem (ES) cells to study and
isolate skeletal muscle progenitors. This is due to the paucity of paraxial mesoderm …

Background Duchenne muscular dystrophy (DMD) is a severe X-linked neuromuscular
childhood disorder that causes progressive muscle weakness and degeneration and results …