[HTML][HTML] Natural products, PGC-1α, and Duchenne muscular dystrophy

I Suntar, A Sureda, T Belwal, AS Silva, RA Vacca… - … Pharmaceutica Sinica B, 2020 - Elsevier
Peroxisome proliferator-activated receptor γ (PPARγ) is a transcriptional coactivator that
binds to a diverse range of transcription factors. PPARγ coactivator 1 (PGC-1) coactivators …

[HTML][HTML] Dystrophin expression in myofibers of Duchenne muscular dystrophy patients following intramuscular injections of normal myogenic cells

D Skuk, B Roy, M Goulet, P Chapdelaine… - Molecular Therapy, 2004 - cell.com
Three Duchenne muscular dystrophy (DMD) patients received injections of myogenic cells
obtained from skeletal muscle biopsies of normal donors. The cells (30× 10 6) were injected …

Imaging survival and function of transplanted cardiac resident stem cells

Z Li, A Lee, M Huang, H Chun, J Chung, P Chu… - Journal of the American …, 2009 - jacc.org
Objectives: The goal of this study is to characterize resident cardiac stem cells (CSCs) and
investigate their therapeutic efficacy in myocardial infarction by molecular imaging methods …

[HTML][HTML] DMPK dosage alterations result in atrioventricular conduction abnormalities in a mouse myotonic dystrophy model

CI Berul, CT Maguire, MJ Aronovitz… - The Journal of …, 1999 - Am Soc Clin Investig
Myotonic dystrophy (DM) is the most common form of muscular dystrophy and is caused by
expansion of a CTG trinucleotide repeat on human chromosome 19. Patients with DM …

[HTML][HTML] Current understanding of molecular pathology and treatment of cardiomyopathy in duchenne muscular dystrophy

TLE Van Westering, CA Betts, MJA Wood - Molecules, 2015 - mdpi.com
Duchenne muscular dystrophy (DMD) is a genetic muscle disorder caused by mutations in
the Dmd gene resulting in the loss of the protein dystrophin. Patients do not only experience …

Long-term expression of erythropoietin in the systemic circulation of mice after intramuscular injection of a plasmid DNA vector.

SK Tripathy, EC Svensson, HB Black… - Proceedings of the …, 1996 - National Acad Sciences
Erythropoietin (Epo)-responsive anemia is a common and debilitating complication of
chronic renal failure and human immunodeficiency virus infection. Current therapy for this …

Gene therapies that restore dystrophin expression for the treatment of Duchenne muscular dystrophy

JN Robinson-Hamm, CA Gersbach - Human genetics, 2016 - Springer
Duchenne muscular dystrophy is one of the most common inherited genetic diseases and is
caused by mutations to the DMD gene that encodes the dystrophin protein. Recent …

Synthetic niche to modulate regenerative potential of MSCs and enhance skeletal muscle regeneration

M Pumberger, TH Qazi, MC Ehrentraut, M Textor… - Biomaterials, 2016 - Elsevier
Severe injury to the skeletal muscle often results in the formation of scar tissue, leading to a
decline in functional performance. Traditionally, tissue engineering strategies for muscle …

The muscular dystrophies: from genes to therapies

RM Lovering, NC Porter, RJ Bloch - Physical therapy, 2005 - academic.oup.com
The genetic basis of many muscular disorders, including many of the more common
muscular dystrophies, is now known. Clinically, the recent genetic advances have improved …

Reliability of hand‐held dynamometry in spinal muscular atrophy

L Merlini, ES Mazzone, A Solari… - Muscle & Nerve: Official …, 2002 - Wiley Online Library
We have assessed the reliability of hand‐held myometry in 33 patients with spinal muscular
atrophy (SMA), testing elbow flexion, handgrip, three‐point pinch, knee flexion, knee …