Purpose To characterize the clinical features and perform linkage analysis of candidate loci
in a large Illinois family with autosomal dominant limb-girdle muscular dystrophy (LGMD) …

Muscular dystrophies represent a group of diseases which may develop in several forms,
and severity of the disease is usually associated with gene mutations. In skeletal muscle …

Daily prednisone improves strength in boys with Duchenne muscular dystrophy, but side
effects are almost universal. We used a different dosing regimen of prednisone to determine …

The review explains why the myotoxic phospholipases A2 and cardiotoxins are such
important tools in the study of the regeneration and maturation of mammalian skeletal …

Abstract Myotonic dystrophy type 1 (DM1) is caused by a CTG nucleotide repeat expansion
within the 3'-untranslated region (3'-UTR) of the Dystrophia Myotonica protein kinase gene …

Dual adeno-associated virus (AAV) technology was developed in 2000 to double the
packaging capacity of the AAV vector. The proof of principle has been demonstrated in …

Cell-based therapy for Duchenne muscular dystrophy patients and mdx mice has proven to
be a safe but ineffective form of treatment. Recently, a group of cells called muscle side …

Various therapeutic approaches have been studied for the treatment of Duchenne muscular
dystrophy (DMD), but none of these approaches have led to significant long-term effects in …

Summary Pluripotent stem (PS)-cell-derived cell types hold promise for treating
degenerative diseases. However, PS cell differentiation is intrinsically heterogeneous; …

Skeletal muscle injury and repair are complex processes, including well‐coordinated steps
of degeneration, inflammation, regeneration, and fibrosis. We have reviewed the recent …