Characterization of myogenic subpopulations has traditionally been performed
independently of their functional performance following transplantation. Using the preplate …

Effects of ex vivo GDNF gene delivery on the degeneration of motoneurons were studied in
the G1H transgenic mouse model of familial ALS carrying a human superoxide dismutase …

Adult skeletal muscle is a postmitotic tissue with an enormous capacity to regenerate upon
injury. This is accomplished by resident stem cells, named satellite cells, which were …

Tissue extracellular matrix (ECM) provides structural support and creates unique
environments for resident cells (Bateman JF, Boot-Handford RP, Lamandé SR. Nat Rev …

In a previous limb-girdle muscular dystrophy type 2D (LGMD2D) clinical trial, robust alpha-
sarcoglycan gene expression was confirmed following intramuscular gene (SGCA) transfer …

Abstract Duchenne Muscular Dystrophy (DMD) is an inherited genetic disorder
characterized by progressive degeneration of muscle tissue, leading to functional disability …

Introduction Duchenne muscular dystrophy (DMD), caused by a lack of the functional
structural protein dystrophin, leads to severe muscle degeneration where the patients are …

The regenerative capacity of skeletal muscle will depend on the number of available satellite
cells and their proliferative capacity. We have measured both parameters in ageing, and …

We have tested the feasibility of muscle-based gene therapy and tissue engineering for
urological dysfunction using highly purified muscle-derived cells (MDC) that display stem …

Duchenne muscular dystrophy (DMD) is a devastating X‐linked muscle disease
characterized by progressive muscle weakness caused by the lack of dystrophin expression …