Duchenne muscular dystrophy (DMD) is a progressive, lethal, muscle wasting disease that
affects 1 of 3500 boys born worldwide. The disease results from mutation of the dystrophin …

Myoblast transplantation was the first quasi-gene therapy to be suggested for Duchenne
muscular dystrophy. Animal experiments established the principles that the missing gene …

In the canine model of Duchenne muscular dystrophy in golden retrievers (GRMD), a point
mutation within the splice acceptor site of intron 6 leads to deletion of exon 7 from the …

A major research challenge is to develop therapeutics that assist with healing damaged
tissues and organs because the human body has limited ability to restore the majority of …

Randomized, placebo-controlled single blinded study was carried out to evaluate the effect
of oral creatine supplementation on cellular energetics, manual muscle test (MMT) score …

Skeletal muscle stem cells, called satellite cells and defined by the transcription factor PAX7,
are responsible for postnatal muscle growth, homeostasis and regeneration. Attempts to …

Stem cells are classically defined by their multipotent, long-term proliferation, and self-
renewal capabilities. Here, we show that increased antioxidant capacity represents an …

Nonhuman primates were used to define myoblast transplantation strategies applicable to
humans. Nevertheless, previous experiments were based on the use of myotoxins …

Introduction Tissue engineering is an innovative field with enormous developments in recent
years. These advances are not only in the understanding of how stem cells can be isolated …

Myoblast transplantation (MT) may be a potential treatment for severe recessive hereditary
myopathies. The limited results of MT in clinical trials led us to improve this technique in …