The non-specific effects of vaccines
F Shann - Archives of disease in childhood, 2010 - adc.bmj.com
The simplistic conventional model of immunisation is no longer valid: we cannot assume that
a vaccine acts independently from other vaccines or that it influences only infections caused …
a vaccine acts independently from other vaccines or that it influences only infections caused …
Non-specific effects of standard measles vaccine at 4.5 and 9 months of age on childhood mortality: randomised controlled trial
P Aaby, CL Martins, ML Garly, C Balé, A Andersen… - Bmj, 2010 - bmj.com
Objective To examine in a randomised trial whether a 25% difference in mortality exists
between 4.5 months and 3 years of age for children given two standard doses of Edmonston …
between 4.5 months and 3 years of age for children given two standard doses of Edmonston …
Measles: old vaccines, new vaccines
DE Griffin, CH Pan - Measles: Pathogenesis and Control, 2009 - Springer
Isolation of measles virus in tissue culture by Enders and colleagues in the 1960s led to the
development of the first measles vaccines. An inactivated vaccine provided only short-term …
development of the first measles vaccines. An inactivated vaccine provided only short-term …
Live vaccine against measles, mumps, and rubella and the risk of hospital admissions for nontargeted infections
Importance In low-income countries, live measles vaccine reduces mortality from causes
other than measles infection. Such nonspecific effects of vaccines might also be important …
other than measles infection. Such nonspecific effects of vaccines might also be important …
Testing the hypothesis that diphtheria–tetanus–pertussis vaccine has negative non-specific and sex-differential effects on child survival in high-mortality countries
P Aaby, C Benn, J Nielsen, IM Lisse, A Rodrigues… - BMJ open, 2012 - bmjopen.bmj.com
Background Measles vaccines (MV) have sex-differential effects on mortality not explained
by protection against measles infection. Objective The authors examined whether whole-cell …
by protection against measles infection. Objective The authors examined whether whole-cell …
Fully immunized child: coverage, timing and sequencing of routine immunization in an urban poor settlement in Nairobi, Kenya
Background More efforts have been put in place to increase full immunization coverage
rates in the last decade. Little is known about the levels and consequences of delaying or …
rates in the last decade. Little is known about the levels and consequences of delaying or …
Non-specific and sex-differential effects of vaccinations on child survival in rural western India
S Hirve, A Bavdekar, S Juvekar, CS Benn, J Nielsen… - Vaccine, 2012 - Elsevier
BACKGROUND: Studies from Africa have suggested marked non-specific effects (NSEs) of
routine vaccinations with effects on child survival. There have been few studies from Asia …
routine vaccinations with effects on child survival. There have been few studies from Asia …
Increased female-male mortality ratio associated with inactivated polio and diphtheria-tetanus-pertussis vaccines: observations from vaccination trials in Guinea …
Background: The 2-fold increase in female mortality after high-titer measles vaccine may
have occurred because many children received diphtheria-tetanus-pertussis (DTP) vaccine …
have occurred because many children received diphtheria-tetanus-pertussis (DTP) vaccine …
Sex differential effects of routine immunizations and childhood survival in rural Malawi
Background: Recent studies from West Africa suggest that routine vaccinations may have
sex differential nontargeted effects. To answer whether these patterns are found elsewhere …
sex differential nontargeted effects. To answer whether these patterns are found elsewhere …
Early diphtheria-tetanus-pertussis vaccination associated with higher female mortality and no difference in male mortality in a cohort of low birthweight children: an …
Background Studies from low-income countries have suggested that diphtheria-tetanus-
pertussis (DTP) vaccine provided after Bacille Calmette-Guerin (BCG) vaccination may have …
pertussis (DTP) vaccine provided after Bacille Calmette-Guerin (BCG) vaccination may have …