Interleukin-7 (IL-7) was initially isolated more than 10 years ago. 1-4 Nevertheless, the
complete set of physiologic roles for this cytokine, especially those involving lymphocyte …

Perforin is a cytolytic mediator produced by killer lymphocytes, and is stored in and released
by cytoplasmic granules. The proteh is partiall, homologous to the terminal components of …

Recent evidence has implicated interleukin-7 (IL-7) as a master regulator of T-cell
homeostasis, based upon its essential role in the homeostatic expansion of naive T-cell …

Impaired immune reconstitution has moved to the forefront of clinical problems limiting
progress in allogeneic bone marrow transplantation (BMT). The identification of therapies …

Natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) use cytotoxic granules
containing perforin and granzymes to lyse infected or malignant host cells, thereby providing …

We have previously demonstrated that human rIL-12 alone can augment the development of
cytotoxic activity in stimulated CD8+ T cells. The present study was undertaken to examine …

The pore-forming protein perforin is preferentially expressed in NK and cytotoxic T cells. To
investigate the molecular regulation of human perforin gene transcription, the activity of the …

We have discussed in the previous sections the recent progress made toward elucidating
the regulatory mechanism of perforin gene transcription and the domain structure of the …

Background: Central nervous system (CNS) infiltration by CD8+ T cells is associated with
neuroinflammation in many neurodegenerative diseases, including HIV-associated …

Regulation of expression of interleukin 7 (IL-7) mRNA is aberrant in the leukemic subset of
cells of chronic lymphocytic leukemia (CLL) patients. The entire coding sequence for IL-7 as …