Cytokine and growth factor signaling mediates essential roles in the differentiation,
proliferation, survival and function of a number of cell lineages. This is achieved via specific …

Cell–cell communication depends on cytokine and growth factor network. Bound to their
receptors on the surface of target cell, these glycoproteins initiate a range of intracellular …

Atopic dermatitis (AD) is a chronic inflammatory skin disease caused by the dysregulation of
cytokines and other immune mediators. JAK/STAT is a classical signal transduction pathway …

OBJECTIVE: T-box expressed in T cells (T-bet) and GATA-binding protein 3 (GATA-3) are
transcriptional factors that play a crucial role in Th1 and Th2 development. We investigated …

Canine atopic dermatitis (AD) is a chronic inflammatory and pruritic skin disease which
shares several characteristics with its human counterpart. In chronic patch test lesions of …

Inflammatory skin diseases include a series of disorders characterized by a strong activation
of the innate and adaptive immune system in which proinflammatory cytokines play a …

As one of the most serious types of psoriasis, pathogenesis of erythrodermic psoriasis (EP)
is unclear so far. In this study, we aimed to detect the levels of Th1/Th2 cytokine-associated …

Suppressor of cytokine signalling (SOCS) proteins bind to certain cytokine receptors, Janus
kinases and signalling molecules to regulate signalling pathways, thus controlling immune …

BACKGROUND: Recently the immune regulatory role of T cell–derived IL-10 in allergic
disease has been extensively studied. In contrast, there is mounting evidence that IL-10 …

Sinomenine has been used to treat autoimmune diseases for centuries. However, the
mechanism underlying its therapeutic effects remains unknown. Increasing recognition of …