Reactive oxygen species (ROS), a group of highly reactive ions and molecules, are
increasingly being appreciated as powerful signaling molecules involved in the regulation of …

Bromelain is a major sulfhydryl proteolytic enzyme found in pineapple plants, having
multiple activities in many areas of medicine. Due to its low toxicity, high efficiency, high …

Cancer cells exhibit a wide range of metabolic phenotypes, ranging from strict aerobic
glycolysis to increased mitochondrial respiration. The cause and utility of this metabolic …

Cancer is one of the main causes of death globally and considered as a major challenge for
the public health system. The high toxicity and the lack of selectivity of conventional …

Bromelain is a key enzyme found in pineapple (Ananas comosus (L.) Merr.); a proteolytic
substance with multiple beneficial effects for human health such as anti-inflammatory …

Accumulated evidence indicates that autophagy is a response of cancer cells to various anti-
cancer therapies. Autophagy is designated as programmed cell death type II, and is …

The utilization of plant-derived supplements for disease prevention and treatment has long
been recognized because of their remarkable potential. Ananas comosus, commonly known …

Background Mycobacterium tuberculosis infection is thought to induce oxidative stress. N-
acetyl-cysteine (NAC) is widely used in patients with chronic pulmonary diseases including …

Bromelain is a concoction of sulfhydryl proteolytic enzymes. Depending upon the site of
extraction it can be regarded as either stem bromelain (SBM)(EC 3.4. 22.32) or fruit …

Here, we investigated the possible anti-cancer properties of bromelain in Kras mutant
human colorectal carcinoma cell lines and a mouse model harboring a Kras mutation. Cell …