In the brain, increases in neural activity drive changes in local blood flow via neurovascular
coupling. The common explanation for increased blood flow (known as functional …

Herein, we review mechanisms regulating cerebral blood flow (CBF), with specific focus on
humans. We revisit important concepts from the older literature and describe the interaction …

We highlight a significant problem that needs to be considered and addressed when
performing functional near-infrared spectroscopy (fNIRS) studies, namely the possibility of …

As the population ages, the incidence of neurodegenerative diseases is increasing. Due to
intensive research, important steps in the elucidation of pathogenetic cascades have been …

The mechanisms of neurovascular coupling contribute to ensuring brain energy supply is
sufficient to meet demand. Despite significant research interest, the mechanisms underlying …

Recently introduced hybrid PET/MR scanners provide the opportunity to measure
simultaneously, and in direct spatial correspondence, both metabolic demand and functional …

There is a growing body of evidencethat indicates that the aging of the brain results from the
decline of energy metabolism. In particular, the neuronal metabolism of glucose declines …

Neuronal activity within the brain evokes local increases in blood flow, a response termed
functional hyperemia. This response ensures that active neurons receive sufficient oxygen …

Energy production in the brain depends almost exclusively on oxidative metabolism.
Neurons have small energy reserves and require a continuous supply of oxygen (O 2). It is …

Neural prostheses have already a long history and yet the cochlear implant remains the only
success story about a longterm sensory function restoration. On the other hand, neural …