The movement of fluid into, through, and out of the brain plays an important role in clearing
metabolic waste. However, there is controversy regarding the mechanisms driving fluid …

Retinal oximetry imaging of retinal blood vessels measures oxygen saturation of
hemoglobin. The imaging technology is non-invasive and reproducible with remarkably low …

Insidious declines in normal aging are well-established. Emerging evidence suggests that
non-pharmacological interventions, specifically cognitive and physical training, may counter …

Rising atmospheric oxygen (O2) levels provided a selective pressure for the evolution of O2‐
dependent micro‐organisms that began with the autotrophic eukaryotes. Since these …

Neurovascular coupling is a fundamental brain mechanism that regulates local cerebral
blood flow (CBF) in response to changes in neuronal activity. Functional imaging techniques …

Brain aging and associated neurodegeneration constitute a major societal challenge as well
as one for the neuroimaging community. A full understanding of the physiological …

Background & Aims Increased plasma ammonia concentration and consequent disruption of
brain energy metabolism could underpin the pathogenesis of hepatic encephalopathy (HE) …

In the brain, increased neural activity is correlated with increases of cerebral blood flow and
tissue oxygenation. However, how cerebral oxygen dynamics are controlled in the behaving …

We recently extended the classic flow–diffusion equation, which relates blood flow to tissue
oxygenation, to take capillary transit time heterogeneity (CTH) into account. Realizing that …

Inhibitory interneurons can evoke vasodilation and vasoconstriction, making them potential
cellular drivers of neurovascular coupling. However, the specific regulatory roles played by …