Executive summary “Depression is a disorder of mood, so mysteriously painful and elusive
in the way it becomes known to the self—to the mediating intellect—as to verge close to …

Criteria for treatment-resistant depression (TRD) and partially responsive depression (PRD)
as subtypes of major depressive disorder (MDD) are not unequivocally defined. In the …

Objective: Estimates of prevalence and burden of treatment-resistant depression (TRD) vary
widely in the literature. This study evaluated the prevalence and burden of TRD and the …

Treatment‐resistant depression (TRD) is common and associated with multiple serious
public health implications. A consensus definition of TRD with demonstrated predictive utility …

Background COMP360 is a proprietary, synthetic formulation of psilocybin being developed
for treatment-resistant depression (TRD), a burdensome, life-threatening illness with high …

Persistent depressive disorder is a chronic mood disorder that is common and often more
disabling than episodic major depression. In DSM-5, the term subsumes several chronic …

Importance The totality of the societal and individual impact of treatment-resistant
depression (TRD) is unknown, as is the potential to prognosticate TRD. The generalizability …

Background Many depressed patients are not able to achieve or sustain symptom remission
despite serial treatment trials–often termed “treatment resistant depression”. A broader …

Major depressive disorder is a leading cause of disability worldwide. Because conventional
therapies are ineffective in many patients, novel strategies are needed to overcome …

The concept of treatment-resistant or treatment-refractory depression (TRD) has evolved
over 40 years since the recognition that some patients minimally benefit from repeated …