Background The efficacy of vaginal progesterone for preventing preterm birth and adverse
perinatal outcomes in singleton gestations with a short cervix has been questioned after …

BACKGROUND At the interface of the external environment and the mucosal surface of the
female reproductive tract (FRT) lies a first-line defense against pathogen invasion that …

Mechanisms underlying the initiation of parturition remain unclear. Throughout most of
pregnancy, uterine quiescence is maintained by elevated progesterone acting through …

Progesterone acting via the progesterone receptor (PR) plays a critical role in maintaining
uterine quiescence during pregnancy. In the present study, we tested the hypothesis that the …

The complement cascade was identified over 100 years ago, yet investigation of its role in
pregnancy remains an area of intense research. Complement inhibitors at the maternal-fetal …

A variety of studies have shown that some activated nuclear receptors (NRs), especially the
glucorticoid receptor, the estrogen receptor and peroxisome proliferator-activated receptor …

High‐dimensional biology (HDB) refers to the simultaneous study of the genetic variants
(DNA variation), transcription (messenger RNA [mRNA]), peptides and proteins, and …

Whereas the essential role of progesterone in the maintenance of pregnancy is accepted
generally, the mechanisms that suppress progesterone's function near term to allow labor …

Complex cytokine networks play an important role in a wide range of reproductive and
pregnancy related processes. Here, we review the current knowledge concerning the impact …

Preterm birth affects approximately 1 out of every 10 births in the United States, leading to
high rates of mortality and long-term negative health consequences. To investigate the …