Amino acid catabolism in Alzheimer's disease brain: friend or foe?
JWD Griffin, PC Bradshaw - Oxidative medicine and cellular …, 2017 - Wiley Online Library
There is a dire need to discover new targets for Alzheimer's disease (AD) drug development.
Decreased neuronal glucose metabolism that occurs in AD brain could play a central role in …
Decreased neuronal glucose metabolism that occurs in AD brain could play a central role in …
β-Carboline as a privileged scaffold for multitarget strategies in Alzheimer's disease therapy
A Beato, A Gori, B Boucherle… - Journal of Medicinal …, 2021 - ACS Publications
The natural β-carboline alkaloids display similarities with neurotransmitters that can be
favorably exploited to design bioactive and bioavailable drugs for Alzheimer's disease (AD) …
favorably exploited to design bioactive and bioavailable drugs for Alzheimer's disease (AD) …
Serotonergic system, cognition, and BPSD in Alzheimer's disease
Abstract Behavioral and Psychological Symptoms of Dementia (BPSD), present in almost
90% of patients with Alzheimer's Disease (AD), cause extensive impairment leading to …
90% of patients with Alzheimer's Disease (AD), cause extensive impairment leading to …
Safety and efficacy of idalopirdine, a 5-HT6 receptor antagonist, in patients with moderate Alzheimer's disease (LADDER): a randomised, double-blind, placebo …
D Wilkinson, K Windfeld… - The Lancet …, 2014 - thelancet.com
Background In human beings, 5-HT 6 receptors are almost exclusively expressed in the
brain, particularly in areas relevant for cognition, such as the hippocampus and frontal …
brain, particularly in areas relevant for cognition, such as the hippocampus and frontal …
Serotonin 5-HT6 Receptor Antagonists for the Treatment of Cognitive Deficiency in Alzheimer's Disease
B Benhamú, M Martín-Fontecha… - Journal of medicinal …, 2014 - ACS Publications
Alzheimer's disease (AD) is one of the most frequent causes of death and disability
worldwide and has a significant clinical and socioeconomic impact. In the search for novel …
worldwide and has a significant clinical and socioeconomic impact. In the search for novel …
Drug repositioning with adaptive graph convolutional networks
Motivation Drug repositioning is an effective strategy to identify new indications for existing
drugs, providing the quickest possible transition from bench to bedside. With the rapid …
drugs, providing the quickest possible transition from bench to bedside. With the rapid …
Microglial dysfunction connects depression and Alzheimer's disease
Alzheimer's disease (AD) and major depressive disorder (MDD) are highly prevalent
neuropsychiatric conditions with intriguing epidemiological overlaps. Depressed patients …
neuropsychiatric conditions with intriguing epidemiological overlaps. Depressed patients …
Cross talk between brain innate immunity and serotonin signaling underlies depressive-like behavior induced by Alzheimer's amyloid-β oligomers in mice
Considerable clinical and epidemiological evidence links Alzheimer's disease (AD) and
depression. However, the molecular mechanisms underlying this connection are largely …
depression. However, the molecular mechanisms underlying this connection are largely …
A comprehensive review of multi-target directed ligands in the treatment of Alzheimer's disease
Alzheimer's disease (AD) is the most common form of dementia affecting specifically older
population. AD is an irreversible neurodegenerative CNS disorder associated with complex …
population. AD is an irreversible neurodegenerative CNS disorder associated with complex …
[HTML][HTML] Constitutive and acquired serotonin deficiency alters memory and hippocampal synaptic plasticity
SP Fernandez, A Muzerelle… - …, 2017 - nature.com
Abstract Serotonin (5-HT) deficiency occurs in a number of brain disorders that affect
cognitive function. However, a direct causal relationship between 5-HT hypo-transmission …
cognitive function. However, a direct causal relationship between 5-HT hypo-transmission …