Turning on the light within: subcortical nuclei of the isodentritic core and their role in Alzheimer's disease pathogenesis

P Theofilas, S Dunlop, H Heinsen… - Journal of Alzheimer's …, 2015 - content.iospress.com
Pharmacological interventions in Alzheimer's disease (AD) are likely to be more efficacious
if administered early in the course of the disease, foregoing the spread of irreversible …

Selective serotonin reuptake inhibitors and Alzheimer's disease

B Mdawar, E Ghossoub, R Khoury - Neural regeneration research, 2020 - journals.lww.com
Given the failure to develop disease-modifying therapies for Alzheimer's disease (AD),
strategies aiming at preventing or delaying the onset of the disease are being prioritized …

[HTML][HTML] Synthesis, computational and experimental pharmacological studies for (thio) ether-triazine 5-HT6R ligands with noticeable action on AChE/BChE and …

K Czarnota-Łydka, S Sudoł-Tałaj… - European Journal of …, 2023 - Elsevier
Alzheimer's disease is becoming a growing problem increasing at a tremendous rate.
Serotonin 5-HT 6 receptors appear to be a particularly attractive target from a therapeutic …

Novel multi-target-directed ligands for Alzheimer's disease: combining cholinesterase inhibitors and 5-HT6 receptor antagonists. Design, synthesis and biological …

A Więckowska, M Kołaczkowski, A Bucki… - European Journal of …, 2016 - Elsevier
As currently postulated, a complex treatment may be key to an effective therapy for
Alzheimer's disease (AD). Recent clinical trials in patients with moderate AD have shown a …

Psychedelics for Alzheimer's disease-related dementia: Unveiling therapeutic possibilities and pathways

JK Sinha, A Trisal, S Ghosh, S Gupta, KK Singh… - Ageing Research …, 2024 - Elsevier
Psychedelics have traditionally been used for spiritual and recreational purposes, but recent
developments in psychotherapy have highlighted their potential as therapeutic agents …

Antagonism of the 5-HT6 receptor–Preclinical rationale for the treatment of Alzheimer's disease

IEM de Jong, A Mørk - Neuropharmacology, 2017 - Elsevier
Antagonism of the 5-HT 6 receptor is a promising approach for the symptomatic treatment of
Alzheimer's disease (AD). There is compelling preclinical evidence for the procognitive …

Highlighting immune system and stress in major depressive disorder, Parkinson's, and Alzheimer's diseases, with a connection with serotonin

AS Correia, A Cardoso, N Vale - International Journal of Molecular …, 2021 - mdpi.com
There is recognition that both stress and immune responses are important factors in a variety
of neurological disorders. Moreover, there is an important role of several neurotransmitters …

Gut biofactory—Neurocompetent metabolites within the gastrointestinal tract. A scoping review

K Skonieczna-Żydecka, K Jakubczyk… - Nutrients, 2020 - mdpi.com
The gut microbiota have gained much scientific attention recently. Apart from unravelling the
taxonomic data, we should understand how the altered microbiota structure corresponds to …

Serotonergic therapies for cognitive symptoms in Alzheimer's disease: rationale and current status

MJ Ramirez, MKP Lai, RM Tordera, PT Francis - Drugs, 2014 - Springer
Alzheimer's disease (AD) is the most common cause of dementia in elderly people.
Research focused on identifying compounds that restore cognition and memory in AD …

Monoaminergic and histaminergic strategies and treatments in brain diseases

G Di Giovanni, D Svob Strac, M Sole… - Frontiers in …, 2016 - frontiersin.org
The monoaminergic systems are the target of several drugs for the treatment of mood, motor
and cognitive disorders as well as neurological conditions. In most cases, advances have …