Angiogenesis, the formation of new blood vessels, is a complex and dynamic process
regulated by various pro-and anti-angiogenic molecules, which plays a crucial role in tumor …

Liver fibrosis and in particular cirrhosis are the major causes of morbidity and mortality of
patients with chronic liver disease. Their prevention or reversal have become major …

Simple Summary Integrins, a superfamily of cell adhesion receptors, were extensively
investigated as therapeutic targets over the last decades, motivated by their multiple …

Integrins are vital surface adhesion receptors that mediate interactions between the
extracellular matrix (ECM) and cells and are essential for cell migration and the …

Endothelial cells transduce the frictional force from blood flow (fluid shear stress) into
biochemical signals that regulate gene expression and cell behavior via specialized …

Integrins are key regulators of communication between cells and with their
microenvironment. Eight members of the integrin superfamily recognize the tripeptide motif …

While the blood vessel is seldom the target tissue, almost all nanomedicine will interact with
blood vessels and blood at some point of time along its life cycle in the human body …

Applications of nanotechnology for treatment, diagnosis, monitoring, and control of
biological systems has recently been referred to as “nanomedicine” by the National Institutes …

Cilengitide, a cyclic RGD pentapeptide, is currently in clinical phase III for treatment of
glioblastomas and in phase II for several other tumors. This drug is the first anti-angiogenic …

Endothelial cell migration is essential to angiogenesis. This motile process is directionally
regulated by chemotactic, haptotactic, and mechanotactic stimuli and further involves …