[HTML][HTML] Mutant p53 as a guardian of the cancer cell
F Mantovani, L Collavin, G Del Sal - Cell Death & Differentiation, 2019 - nature.com
Forty years of research have established that the p53 tumor suppressor provides a major
barrier to neoplastic transformation and tumor progression by its unique ability to act as an …
barrier to neoplastic transformation and tumor progression by its unique ability to act as an …
[HTML][HTML] Systems biology of cancer metastasis
Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series
of concurrent, partially overlapping processes, as successfully metastasizing cells assume …
of concurrent, partially overlapping processes, as successfully metastasizing cells assume …
[HTML][HTML] Dissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma
Little is known about the transcriptomic plasticity and adaptive mechanisms of circulating
tumor cells (CTCs) during hematogeneous dissemination. Here we interrogate the …
tumor cells (CTCs) during hematogeneous dissemination. Here we interrogate the …
ER chaperone GRP78/BiP translocates to the nucleus under stress and acts as a transcriptional regulator
Cancer cells are commonly subjected to endoplasmic reticulum (ER) stress. To gain survival
advantage, cancer cells exploit the adaptive aspects of the unfolded protein response such …
advantage, cancer cells exploit the adaptive aspects of the unfolded protein response such …
Nonsense-mediated RNA decay: an emerging modulator of malignancy
K Tan, DG Stupack, MF Wilkinson - Nature Reviews Cancer, 2022 - nature.com
Nonsense-mediated RNA decay (NMD) is a highly conserved RNA turnover pathway that
selectively degrades RNAs harbouring truncating mutations that prematurely terminate …
selectively degrades RNAs harbouring truncating mutations that prematurely terminate …
Ubiquitin ligases in oncogenic transformation and cancer therapy
The cellular response to external stress signals and DNA damage depends on the activity of
ubiquitin ligases (E3s), which regulate numerous cellular processes, including homeostasis …
ubiquitin ligases (E3s), which regulate numerous cellular processes, including homeostasis …
[HTML][HTML] Phosphorylation of PDHA by AMPK drives TCA cycle to promote cancer metastasis
Cancer metastasis accounts for the major cause of cancer-related deaths. How
disseminated cancer cells cope with hostile microenvironments in secondary site for full …
disseminated cancer cells cope with hostile microenvironments in secondary site for full …
[HTML][HTML] The force awakens: metastatic dormant cancer cells
SY Park, JS Nam - Experimental & Molecular Medicine, 2020 - nature.com
Recurrent cancer that spreads to distant sites is the leading cause of disease-related death
among cancer patients. Cancer cells are likely to disseminate during cancer progression …
among cancer patients. Cancer cells are likely to disseminate during cancer progression …
Beyond genetics: driving cancer with the tumour microenvironment behind the wheel
Cancer has long been viewed as a genetic disease of cumulative mutations. This notion is
fuelled by studies showing that ageing tissues are often riddled with clones of complex …
fuelled by studies showing that ageing tissues are often riddled with clones of complex …
[HTML][HTML] The lncRNA MACC1-AS1 promotes gastric cancer cell metabolic plasticity via AMPK/Lin28 mediated mRNA stability of MACC1
Y Zhao, Y Liu, L Lin, Q Huang, W He, S Zhang, S Dong… - Molecular cancer, 2018 - Springer
Background Metabolic plasticity has been increasingly thought to be a determinant of tumor
growth and metastasis. MACC1, a transcriptional regulator of MET, was recognized as an …
growth and metastasis. MACC1, a transcriptional regulator of MET, was recognized as an …