The cytochrome P450 (CYP) enzyme family is the most important enzyme system catalyzing
the phase 1 metabolism of pharmaceuticals and other xenobiotics such as herbal remedies …

Resveratrol is one of the most widely studied polyphenols and it has been assigned a
plethora of metabolic effects with potential health benefits. Given its low bioavailability and …

Animal models are commonly used in the preclinical development of new drugs to predict
the metabolic behaviour of new compounds in humans. It is, however, important to realise …

Irinotecan is a topoisomerase inhibitor, widely used in treatment of malignancies including
pancreatic ductal adenocarcinoma (PDAC) as part of the FOLFIRINOX regimen prescribed …

Caffeine (1, 3, 7-trimethylxanthine) is the most consumed psychoactive substance in the
world, acting by means of antagonism to adenosine receptors, mainly A1 and A2A. Coffee is …

The aim of this review is to analyse critically the recent literature on the clinical
pharmacokinetics and pharmacodynamics of tacrolimus in solid organ transplant recipients …

Abstract Cytochrome P450 3A4 (CYP3A4) metabolizes∼ 50% of all clinically used drugs.
Although CYP3A4 expression varies widely between individuals, the contribution of genetic …

The management of cancer involves procedures, which include surgery, radiotherapy and
chemotherapy. Development of chemoresistance is a persistent problem during the …

Abstract Introduction Resveratrol (3, 5, 4'-trihydroxy-trans-stilbene) is a polyphenol obtained
from diverse groups of plants, especially in the muscadine grape, red wine, lingonberry …

The human immunodeficiency virus-1 (HIV-1) enters target cells by binding its envelope
glycoprotein gp120 to the CD4 receptor and/or coreceptors such as CC chemokine receptor …