Naturally occurring antioxidants such as vitamin E, β‐carotene, and vitamin C can inhibit the
oxidative modification of low density lipoproteins. This action could positively influence the …

Background—Hypercholesterolemia is considered a major risk factor for the development of
atherosclerosis. Enhanced lipid peroxidation and persistent platelet activation can be …

A large body of evidence indicates that endothelial dysfunction is a characteristic of patients
with essential hypertension. By definition, endothelial dysfunction is a functional and …

Aspirin (acetylsalicylic acid, ASA), which is recommended for primary and secondary
prevention in diabetes mellitus (DM), has been shown to have a lower antiplatelet activity in …

Background—Oxidant stress has been implicated in the pathogenesis of atherothrombosis
and other vascular disorders accompanied by endothelial dysfunction. Glutathione …

Background—Hypertensive patients with renovascular disease (RVD) may be exposed to
increased oxidative stress, possibly related to activation of the renin-angiotensin system …

Cellular glutathione peroxidase (GPx-1) is the most abundant intracellular isoform of the
GPx antioxidant enzyme family. In this study, we hypothesized that GPx-1 deficiency directly …

Coronary heart disease (CHD) is the leading single cause of death in the United States and
most Western countries, killing more than 400,000 Americans per year. Although CHD often …

Background—Oxidative stress is involved in the onset of several degenerative disorders,
and epidemiological studies indicate that a high intake of dietary antioxidants, as in the case …

In vitro studies have shown that α-lipoic acid (LA) is an antioxidant. There is a paucity of
studies on LA supplementation in humans. Therefore, the aim of this study was to assess the …