Thyroid hormone transporters at the plasma membrane govern intracellular bioavailability of
thyroid hormone. Monocarboxylate transporter (MCT) 8 and MCT10, organic anion …

Thyroid hormones have long been known to have a range of effects on the cardiovascular
system. However, significant knowledge gaps exist concerning the precise molecular and …

Background: Thyrotoxicosis has multiple etiologies, manifestations, and potential therapies.
Appropriate treatment requires an accurate diagnosis and is influenced by coexisting …

Resistance to thyroid hormone (RTH) is a clinical syndrome defined by impaired sensitivity
to thyroid hormone (TH) and its more common form is caused by mutations in the thyroid …

More than a century after the discovery of L-Thyroxine, the main thyroid hormone secreted
solely by the thyroid gland, several metabolites of this iodinated, tyrosine-derived ancestral …

There are two genes that express the major thyroid hormone receptor isoforms. Mutations in
both these genes have given rise to Resistance to Thyroid Hormone (RTH) syndromes …

Thyroid hormone (TH) is indispensable for normal embryonic and fetal development.
Throughout gestation TH is provided by the mother via the placenta, later in pregnancy the …

Background: Discrepant thyroid function tests (TFTs) are typical of inappropriate secretion of
TSH (IST), a rare entity encompassing TSH-secreting adenomas (TSHoma) and Resistance …

The aim of the study is to describe the clinical features of two unrelated patients with
resistance to thyroid hormones (RTH), the first, a total thyroidectomized patient, and the …

Context Resistance to thyroid hormone-β (RTH-β) is an autosomal dominant disorder
characterized by reduced sensitivity of target tissues to thyroid hormones (THs). Individuals …