This review of the familial tumor syndromes involving the endocrine organs is focused on
discussing the main updates on the upcoming fifth edition of the WHO Classification of …

Neuroendocrine neoplasms (NENs) are a group of heterogeneous tumors with
neuroendocrine differentiation that can arise from any organ. They account for 2% of all …

Context The skeletal involvement of multiple endocrine neoplasia type 1-related primary
hyperparathyroidism (MHPT) is not exactly the same as that of sporadic primary …

Objective Multiple endocrine neoplasia type 4 (MEN4) is caused by a CDKN1B germline
mutation first described in 2006. Its estimated prevalence is less than one per million. The …

Primary hyperparathyroidism (PHPT), a relatively common disorder characterized by
hypercalcemia with raised or inappropriately normal serum parathyroid hormone (PTH) …

Multiple endocrine neoplasia type 1 (MEN1), an autosomal-dominantly inherited tumor
syndrome, is classically defined by tumors arising from the “3 Ps”: Parathyroids, Pituitary …

Adrenocortical carcinoma (adrenal cortex‑derived cancer), an orphan malignancy, is a very
aggressive disease that affects both adults and children with an annual incidence of 1‑2 …

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Dear Editor, Multiple endocrine neoplasia 1 (MEN1) syndrome, a tumor predisposition
disease caused by MEN1 germline mutation, is characterized by combined occurrence of …

Background Multiple Endocrine Neoplasia type 1 is a rare genetic syndrome mainly caused
by mutations of MEN1 gene and characterized by a combination of several endocrine and …