Increasing placebo responses over time in US clinical trials of neuropathic pain
Recent failures of clinical trials of novel analgesics designed to treat neuropathic pain have
led to much speculation about the underlying reasons. One often discussed possibility is that …
led to much speculation about the underlying reasons. One often discussed possibility is that …
Expectancies as core features of mental disorders
Learning theory, attentional processes, social influences, and biological determinants
contribute to the development, persistence, and modification of expectancies. Psychological …
contribute to the development, persistence, and modification of expectancies. Psychological …
[HTML][HTML] Meta-analysis of neural systems underlying placebo analgesia from individual participant fMRI data
The brain systems underlying placebo analgesia are insufficiently understood. Here we
performed a systematic, participant-level meta-analysis of experimental functional …
performed a systematic, participant-level meta-analysis of experimental functional …
[HTML][HTML] Brain connectivity predicts placebo response across chronic pain clinical trials
Placebo response in the clinical trial setting is poorly understood and alleged to be driven by
statistical confounds, and its biological underpinnings are questioned. Here we identified …
statistical confounds, and its biological underpinnings are questioned. Here we identified …
Interoceptive inference: From computational neuroscience to clinic
The central and autonomic nervous systems can be defined by their anatomical, functional
and neurochemical characteristics, but neither functions in isolation. For example …
and neurochemical characteristics, but neither functions in isolation. For example …
Association between placebo-activated neural systems and antidepressant responses: neurochemistry of placebo effects in major depression
Importance High placebo responses have been observed across a wide range of
pathologies, severely impacting drug development. Objective To examine neurochemical …
pathologies, severely impacting drug development. Objective To examine neurochemical …
[HTML][HTML] Effects of the Mu opioid receptor polymorphism (OPRM1 A118G) on pain regulation, placebo effects and associated personality trait measures
Mu-opioid receptors (MOPRs) are critically involved in the modulation of pain and analgesia,
and represent a candidate mechanism for the development of biomarkers of pain conditions …
and represent a candidate mechanism for the development of biomarkers of pain conditions …
[HTML][HTML] The role of expectation and beliefs on the effects of non-invasive brain stimulation
Non-invasive brain stimulation (NIBS) techniques are used in clinical and cognitive
neuroscience to induce a mild magnetic or electric field in the brain to modulate behavior …
neuroscience to induce a mild magnetic or electric field in the brain to modulate behavior …
Endogenous opiates and behavior: 2014
RJ Bodnar - Peptides, 2016 - Elsevier
This paper is the thirty-seventh consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2014 …
concerning the endogenous opioid system. It summarizes papers published during 2014 …
[HTML][HTML] A Bayesian perspective on sensory and cognitive integration in pain perception and placebo analgesia
D Anchisi, M Zanon - PloS one, 2015 - journals.plos.org
The placebo effect is a component of any response to a treatment (effective or inert), but we
still ignore why it exists. We propose that placebo analgesia is a facet of pain perception …
still ignore why it exists. We propose that placebo analgesia is a facet of pain perception …