Experimental and clinical biomarkers for progressive evaluation of neuropathology and therapeutic interventions for acute and chronic neurological disorders

DS Reddy, HN Abeygunaratne - International Journal of Molecular …, 2022 - mdpi.com
This article describes commonly used experimental and clinical biomarkers of neuronal
injury and neurodegeneration for the evaluation of neuropathology and monitoring of …

Therapeutic strategies aimed at improving neuroplasticity in Alzheimer disease

MF Colavitta, FJ Barrantes - Pharmaceutics, 2023 - mdpi.com
Alzheimer disease (AD) is the most prevalent form of dementia among elderly people.
Owing to its varied and multicausal etiopathology, intervention strategies have been highly …

[HTML][HTML] Western diet consumption impairs memory function via dysregulated hippocampus acetylcholine signaling

AMR Hayes, LT Lauer, AE Kao, S Sun, ME Klug… - Brain, behavior, and …, 2024 - Elsevier
Western diet (WD) consumption during early life developmental periods is associated with
impaired memory function, particularly for hippocampus (HPC)-dependent processes. We …

Circulating extracellular choline acetyltransferase regulates inflammation

AH Gabalski, A Tynan, T Tsaava, JH Li… - Journal of Internal …, 2024 - Wiley Online Library
Abstract Background Choline acetyltransferase (ChAT) is required for the biosynthesis of
acetylcholine, the molecular mediator that inhibits cytokine production in the cholinergic anti …

Association between serum iron, blood lead, cadmium, mercury, selenium, manganese and low cognitive performance in old adults from National Health and Nutrition …

K Lu, T Liu, X Wu, J Zhong, Z Ou, W Wu - British Journal of Nutrition, 2023 - cambridge.org
Cognitive decline is a public health problem for the world's ageing population. This study
was to evaluate the relationships between serum Fe, blood Pb, Cd, Hg, Se and Mn and …

Salivary Aβ1–42 may be a quick-tested biomarker for clinical use in Alzheimer's disease: a meta-analysis

Z Fan, Z Li, S Zhao, Y Chen, Y Su, G Peng, B Luo - Journal of Neurology, 2023 - Springer
Objective Alzheimer's disease (AD) is the most prevalent form of dementia among the aging
population. Cumulative studies aim to find non-invasive biomarkers in the early stages of …

Melatonin Attenuates Arsenic-Induced Neurotoxicity in Rats Through the Regulation of miR-34a/miR-144 in Sirt1/Nrf2 Pathway

N Najafi, S Barangi, Z Moosavi… - Biological trace element …, 2024 - Springer
Arsenic (As) exposure is known to cause several neurological disorders through various
molecular mechanisms such as oxidative stress, apoptosis, and autophagy. In the current …

Chinese herbal extracts exert neuroprotective effect in Alzheimer's disease mouse through the dopaminergic synapse/apoptosis signaling pathway

Q Huang, C Zhang, S Qu, S Dong, Q Ma… - Frontiers in …, 2022 - frontiersin.org
Background: Alzheimer's disease (AD) as an age-related, irreversible neurodegenerative
disease, characterized by cognitive dysfunction, has become progressively serious with a …

Interaction between ω-6 fatty acids intake and blood cadmium on the risk of low cognitive performance in older adults from National Health and Nutrition Examination …

G Huang, G Ren - BMC geriatrics, 2022 - Springer
Background Identifying preventable diets and environmental exposure is essential to
ensuring the health of the aging population. This study evaluated the interaction effect …

The major hypotheses of Alzheimer's disease: related nanotechnology-based approaches for its diagnosis and treatment

C Cáceres, B Heusser, A Garnham, E Moczko - Cells, 2023 - mdpi.com
Alzheimer's disease (AD) is a well-known chronic neurodegenerative disorder that leads to
the progressive death of brain cells, resulting in memory loss and the loss of other critical …