The role of m6A RNA methylation in cancer metabolism
Y An, H Duan - Molecular cancer, 2022 - Springer
Metabolic reprogramming is one of the main characteristics of malignant tumors, which is
due to the flexible changes of cell metabolism that can meet the needs of cell growth and …
due to the flexible changes of cell metabolism that can meet the needs of cell growth and …
The role of PI3K/AKT/mTOR signaling in hepatocellular carcinoma metabolism
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths in
the world. Metabolic reprogramming is considered a new hallmark of cancer, but it remains …
the world. Metabolic reprogramming is considered a new hallmark of cancer, but it remains …
Targeting glucose metabolism to suppress cancer progression: prospective of anti-glycolytic cancer therapy
AF Abdel-Wahab, W Mahmoud, RM Al-Harizy - Pharmacological research, 2019 - Elsevier
Most solid tumor cells adapt to their heterogeneous microenvironment by depending largely
on aerobic glycolysis for energy production, a phenomenon called the Warburg effect, which …
on aerobic glycolysis for energy production, a phenomenon called the Warburg effect, which …
Transcriptional regulation of the Warburg effect in cancer by SIX1
L Li, Y Liang, L Kang, Y Liu, S Gao, S Chen, Y Li… - Cancer cell, 2018 - cell.com
Aerobic glycolysis (the Warburg effect) facilitates tumor growth, and drugs targeting aerobic
glycolysis are being developed. However, how the Warburg effect is directly regulated is …
glycolysis are being developed. However, how the Warburg effect is directly regulated is …
GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer
Triple negative breast cancer (TNBC) is a deadly form of breast cancer due to the
development of resistance to chemotherapy affecting over 30% of patients. New …
development of resistance to chemotherapy affecting over 30% of patients. New …
[HTML][HTML] Regulation of innate immunity by Nrf2
D van der Horst, ME Carter-Timofte… - Current Opinion in …, 2022 - Elsevier
The transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2) has been mainly
investigated as a regulator of redox homeostasis. However, research over the past years …
investigated as a regulator of redox homeostasis. However, research over the past years …
The Warburg effect: a score for many instruments in the concert of cancer and cancer niche cells
M Jaworska, J Szczudło, A Pietrzyk, J Shah… - Pharmacological …, 2023 - Springer
Although Warburg's discovery of intensive glucose uptake by tumors, followed by lactate
fermentation in oxygen presence of oxygen was made a century ago, it is still an area of …
fermentation in oxygen presence of oxygen was made a century ago, it is still an area of …
[HTML][HTML] Drug resistance in pancreatic cancer: Impact of altered energy metabolism
C Grasso, G Jansen, E Giovannetti - Critical reviews in oncology …, 2017 - Elsevier
Pancreatic cancer is a highly deadly disease: almost all patients develop metastases and
conventional treatments have little impact on survival. Therapeutically, this tumor is poorly …
conventional treatments have little impact on survival. Therapeutically, this tumor is poorly …
HSP70 and HSP90 in cancer: cytosolic, endoplasmic reticulum and mitochondrial chaperones of tumorigenesis
Z Albakova, Y Mangasarova, A Albakov… - Frontiers in …, 2022 - frontiersin.org
HSP70 and HSP90 are two powerful chaperone machineries involved in survival and
proliferation of tumor cells. Residing in various cellular compartments, HSP70 and HSP90 …
proliferation of tumor cells. Residing in various cellular compartments, HSP70 and HSP90 …
Molecular mechanisms of drug resistance in glioblastoma
MA Dymova, EV Kuligina, VA Richter - International journal of molecular …, 2021 - mdpi.com
Glioblastoma multiforme (GBM) is the most common and fatal primary brain tumor, is highly
resistant to conventional radiation and chemotherapy, and is not amenable to effective …
resistant to conventional radiation and chemotherapy, and is not amenable to effective …