Overcoming cancer therapeutic bottleneck by drug repurposing

Z Zhang, L Zhou, N Xie, EC Nice, T Zhang… - Signal transduction and …, 2020 - nature.com
Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …

Equol: a bacterial metabolite from the daidzein isoflavone and its presumed beneficial health effects

B Mayo, L Vázquez, AB Flórez - Nutrients, 2019 - mdpi.com
Epidemiological data suggest that regular intake of isoflavones from soy reduces the
incidence of estrogen-dependent and aging-associated disorders, such as menopause …

Endocrine disrupting chemicals and breast cancer: a systematic review of epidemiological studies

MLY Wan, VA Co, H El-Nezami - Critical Reviews in Food Science …, 2022 - Taylor & Francis
Abstract Background Endocrine-disrupting compounds (EDCs) are ubiquitous substances
that are found in our everyday lives, including pesticides, plasticizers, pharmaceutical …

The pros and cons of phytoestrogens

HB Patisaul, W Jefferson - Frontiers in neuroendocrinology, 2010 - Elsevier
Phytoestrogens are plant derived compounds found in a wide variety of foods, most notably
soy. A litany of health benefits including a lowered risk of osteoporosis, heart disease, breast …

Flavonoids and other polyphenols act as epigenetic modifiers in breast cancer

P Selvakumar, A Badgeley, P Murphy, H Anwar… - Nutrients, 2020 - mdpi.com
Breast cancer is a common cancer that occurs due to different epigenetic alterations and
genetic mutations. Various epidemiological studies have demonstrated an inverse …

Breast and gut microbiota action mechanisms in breast cancer pathogenesis and treatment

A Laborda-Illanes, L Sanchez-Alcoholado… - Cancers, 2020 - mdpi.com
Simple Summary In this review we discuss the recent knowledge about the role of breast
and gut microbiome in the pathogenesis of breast cancer. We examine the proposed …

Nutraceuticals: facts and fiction

JC Espín, MT García-Conesa, FA Tomás-Barberán - Phytochemistry, 2007 - Elsevier
Epidemiological studies show a link between the consumption of plant-derived foods and a
range of health benefits. These benefits have been associated, at least partially, to some of …

Lignans and human health

H Adlercreutz - Critical reviews in clinical laboratory sciences, 2007 - Taylor & Francis
This review focuses on the possible role in human health of the consumption of lignan-rich
foods. Most of the plant lignans in human foods are converted by the intestinal microflora in …

Soy isoflavones consumption and risk of breast cancer incidence or recurrence: a meta-analysis of prospective studies

JY Dong, LQ Qin - Breast cancer research and treatment, 2011 - Springer
Numbers of epidemiologic studies assessing soy consumption and risk of breast cancer
have yielded inconsistent results. We aimed to examine the association between soy …

Association between soy isoflavone intake and breast cancer risk for pre-and post-menopausal women: a meta-analysis of epidemiological studies

M Chen, Y Rao, Y Zheng, S Wei, Y Li, T Guo, P Yin - PloS one, 2014 - journals.plos.org
Background Conclusions drawn from meta-analyses on the association between soy
isoflavone intake and breast cancer risk for pre-and post-menopausal women are not fully …