The unfolded protein response (UPR) is a highly conserved pathway that allows the cell to
manage endoplasmic reticulum (ER) stress that is imposed by the secretory demands …

Aneuploidy has been recognized as a hallmark of tumorigenesis for more than 100 years,
but the connection between chromosomal errors and malignant growth has remained …

Biological aging is associated with a reduction in the reparative and regenerative potential
in tissues and organs. This reduction manifests as a decreased physiological reserve in …

Cancer heterogeneity, a hallmark enabling clonal survival and therapy resistance, is shaped
by active immune responses. Antigen-specific T cells can control cancer, as revealed …

Aberrant chromosomal architecture, ranging from small insertions or deletions to large
chromosomal alterations, is one of the most common characteristics of cancer genomes …

The immune system deploys a multitude of innate and adaptive mechanisms not only to
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …

Some of the anti-neoplastic effects of anthracyclines in mice originate from the induction of
innate and T cell–mediated anticancer immune responses. Here we demonstrate that …

Highlights•Genomics analyses to identify the targets of cancer immunoediting and design
personalized cancer immunotherapy.•Emerging role of innate immune cells (NK, DC …

The endoplasmic reticulum (ER) is an essential organelle in eukaryotic cells for the storage
and regulated release of calcium and as the entrance to the secretory pathway. Protein …

Aging is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. This deterioration is the primary risk factor for …