Whole-genome doubling (WGD) is common in human cancers, occurring early in
tumorigenesis and generating genetically unstable tetraploid cells that fuel tumour …

Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit
immune responses specific for dead cell-associated antigens. However, multiple stimuli can …

The term 'immunogenic cell death'(ICD) denotes an immunologically unique type of
regulated cell death that enables, rather than suppresses, T cell-driven immune responses …

Immunogenic cell death (ICD) converts dying cancer cells into a therapeutic vaccine and
stimulates antitumor immune responses. Here we unravel the results of an unbiased screen …

Poorly immunogenic tumor cells evade host immunity and grow even in the presence of an
intact immune system, but the complex mechanisms regulating tumor immunogenicity have …

Depending on the initiating stimulus, cancer cell death can be immunogenic or
nonimmunogenic. Immunogenic cell death (ICD) involves changes in the composition of the …

Exploring a rational delivery system of integrating chemotherapy with immunotherapy to
broaden benefits of cancer immunochemotherapy is still under challenge. Herein, we …

Fundamental cancer research and the development of efficacious antineoplastic treatments
both rely on experimental systems in which the relationship between malignant cells and …

Inflammation can be either beneficial or detrimental to the liver, depending on multiple
factors. Mild (ie, limited in intensity and destined to resolve) inflammatory responses have …

Conventional chemotherapeutics and targeted antineoplastic agents have been developed
based on the simplistic notion that cancer constitutes a cell-autonomous genetic or …