Whole-genome doubling confers unique genetic vulnerabilities on tumour cells
RJ Quinton, A DiDomizio, MA Vittoria, K Kotýnková… - Nature, 2021 - nature.com
Whole-genome doubling (WGD) is common in human cancers, occurring early in
tumorigenesis and generating genetically unstable tetraploid cells that fuel tumour …
tumorigenesis and generating genetically unstable tetraploid cells that fuel tumour …
Consensus guidelines for the detection of immunogenic cell death
O Kepp, L Senovilla, I Vitale, E Vacchelli… - …, 2014 - Taylor & Francis
Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit
immune responses specific for dead cell-associated antigens. However, multiple stimuli can …
immune responses specific for dead cell-associated antigens. However, multiple stimuli can …
Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology
The term 'immunogenic cell death'(ICD) denotes an immunologically unique type of
regulated cell death that enables, rather than suppresses, T cell-driven immune responses …
regulated cell death that enables, rather than suppresses, T cell-driven immune responses …
Crizotinib-induced immunogenic cell death in non-small cell lung cancer
Immunogenic cell death (ICD) converts dying cancer cells into a therapeutic vaccine and
stimulates antitumor immune responses. Here we unravel the results of an unbiased screen …
stimulates antitumor immune responses. Here we unravel the results of an unbiased screen …
The Hippo pathway kinases LATS1/2 suppress cancer immunity
T Moroishi, T Hayashi, WW Pan, Y Fujita, MV Holt… - Cell, 2016 - cell.com
Poorly immunogenic tumor cells evade host immunity and grow even in the presence of an
intact immune system, but the complex mechanisms regulating tumor immunogenicity have …
intact immune system, but the complex mechanisms regulating tumor immunogenicity have …
Immunogenic cell death in cancer therapy
Depending on the initiating stimulus, cancer cell death can be immunogenic or
nonimmunogenic. Immunogenic cell death (ICD) involves changes in the composition of the …
nonimmunogenic. Immunogenic cell death (ICD) involves changes in the composition of the …
Immunogenic hybrid nanovesicles of liposomes and tumor-derived nanovesicles for cancer immunochemotherapy
M Hu, J Zhang, L Kong, Y Yu, Q Hu, T Yang, Y Wang… - Acs Nano, 2021 - ACS Publications
Exploring a rational delivery system of integrating chemotherapy with immunotherapy to
broaden benefits of cancer immunochemotherapy is still under challenge. Herein, we …
broaden benefits of cancer immunochemotherapy is still under challenge. Herein, we …
Mouse models in oncoimmunology
L Zitvogel, JM Pitt, R Daillère, MJ Smyth… - Nature Reviews …, 2016 - nature.com
Fundamental cancer research and the development of efficacious antineoplastic treatments
both rely on experimental systems in which the relationship between malignant cells and …
both rely on experimental systems in which the relationship between malignant cells and …
[HTML][HTML] Decoding cell death signals in liver inflammation
Inflammation can be either beneficial or detrimental to the liver, depending on multiple
factors. Mild (ie, limited in intensity and destined to resolve) inflammatory responses have …
factors. Mild (ie, limited in intensity and destined to resolve) inflammatory responses have …
Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance
Conventional chemotherapeutics and targeted antineoplastic agents have been developed
based on the simplistic notion that cancer constitutes a cell-autonomous genetic or …
based on the simplistic notion that cancer constitutes a cell-autonomous genetic or …