World population has been continuously increasing and progressively aging. Aging is
characterized by a complex and intraindividual process associated with nine major cellular …

Immunotherapy, where the patient's own immune system is exploited to eliminate tumor
cells, has become one of the most prominent new cancer treatment options in the last …

Polyploidy (or whole-genome duplication) is the condition of having more than two basic
sets of chromosomes. Polyploidization is well tolerated in many species and can lead to …

Mitosis is a delicate event that must be executed with high fidelity to ensure genomic
stability. Recent work has provided insight into how mitotic errors shape cancer genomes by …

Immunotherapy provides the best approach to reduce the high mortality of metastatic breast
cancer (BC). We demonstrate a chemo-immunotherapy approach, which utilizes a liposomal …

The expression “immunogenic cell death”(ICD) refers to a functionally unique form of cell
death that facilitates (instead of suppressing) a T cell-dependent immune response specific …

The immunogenic demise of cancer cells can be induced by various chemotherapeutics,
such as anthracyclines and oxaliplatin, and provokes an immune response against tumor …

The combination of relative nutrient deprivation and dysregulation of protein synthesis make
malignant cells especially prone to protein misfolding. Endoplasmic reticulum stress, which …

The immunosurveillance theory postulates that tumors evolve and progress in an
uncontrolled fashion only when anticancer immune responses fail. Natural …

As tumors accumulate genetic alterations, an evolutionary process occurs in which
genetically distinct subclonal populations of cells co-exist, resulting in intratumor genetic …